Meridianin C

Cat. No.: HY-W107409 Purity: 96.06%: Data Sheet
COA

SDS
Handling Instructions
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Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation.

For research use only. We do not sell to patients.

Meridianin C Chemical Structure

CAS No. : 213473-00-8

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	Get quote	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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This product is a controlled substance and not for sale in your territory.

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Description

Molecular Weight

289.13

Formula

C₁₂H₉BrN₄

CAS No.

213473-00-8

Appearance

Solid

Color

Light yellow to yellow

SMILES

NC1=NC=CC(C2=CNC3=C2C=C(Br)C=C3)=N1

Structure Classification

Initial Source

Marine natural products

marine

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (345.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4587 mL	17.2933 mL	34.5865 mL
5 mM	0.6917 mL	3.4587 mL	6.9173 mL
10 mM	0.3459 mL	1.7293 mL	3.4587 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.06%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (250 KB) HNMR (271 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Meridianin C inhibits the growth of YD-10B human tongue cancer cells through macropinocytosis and the down-regulation of Dickkopf-related protein-3

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4587 mL	17.2933 mL	34.5865 mL	86.4663 mL
	5 mM	0.6917 mL	3.4587 mL	6.9173 mL	17.2933 mL
	10 mM	0.3459 mL	1.7293 mL	3.4587 mL	8.6466 mL
	15 mM	0.2306 mL	1.1529 mL	2.3058 mL	5.7644 mL
	20 mM	0.1729 mL	0.8647 mL	1.7293 mL	4.3233 mL
	25 mM	0.1383 mL	0.6917 mL	1.3835 mL	3.4587 mL
	30 mM	0.1153 mL	0.5764 mL	1.1529 mL	2.8822 mL
	40 mM	0.0865 mL	0.4323 mL	0.8647 mL	2.1617 mL
	50 mM	0.0692 mL	0.3459 mL	0.6917 mL	1.7293 mL
	60 mM	0.0576 mL	0.2882 mL	0.5764 mL	1.4411 mL
	80 mM	0.0432 mL	0.2162 mL	0.4323 mL	1.0808 mL
	100 mM	0.0346 mL	0.1729 mL	0.3459 mL	0.8647 mL

Meridianin C Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Meridianin C213473-00-8OthersInhibitorinhibitorinhibit

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Meridianin C

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