2. GPCR/G Protein
  3. ICMT
  4. CAY10677

CAY10677 (compound 15) is a potent ICMT inhibitor that inhibits cancer cell proliferation. CAY10677 has good PAMPA penetration.

For research use only. We do not sell to patients.

CAY10677

CAY10677 Chemical Structure

CAS No. : 1443253-20-0

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Description

CAY10677 (compound 15) is a potent ICMT inhibitor that inhibits cancer cell proliferation. CAY10677 has good PAMPA penetration[1].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
1.65 μM
Compound: 15
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 72 hrs by MTT assay
[PMID: 23514631]
IMR-90 IC50
2.65 μM
Compound: 15
Antiproliferative activity against human IMR90 cells after 72 hrs by MTT assay
Antiproliferative activity against human IMR90 cells after 72 hrs by MTT assay
[PMID: 23514631]
MDA-MB-231 IC50
2.48 μM
Compound: 15
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay
[PMID: 23514631]
MIA PaCa-2 IC50
1.6 μM
Compound: 15
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay
Antiproliferative activity against human MIAPaCa2 cells after 72 hrs by MTT assay
[PMID: 23514631]
PC-3 IC50
2.55 μM
Compound: 15
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay
[PMID: 23514631]
Sf9 IC50
0.86 μM
Compound: 15
Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-biotin-S-farnesyl-L-cysteine after 30 mins
Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as transfer of methyl group from [3H]-S-adenosylmethionine to [3H]-biotin-S-farnesyl-L-cysteine after 30 mins
[PMID: 23514631]
Molecular Weight

407.59

Formula

C25H37N5
CAS No.
SMILES

CCN(CC1=CN(C2=CC=C(C=C21)C3=CN=C(N=C3)N)CCCCCCCC)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CAY10677 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAY106771443253-20-0CAY 10677CAY-10677ICMTIsoprenylcysteine carboxyl methyltransferasePAMPA permeabilityInhibitorinhibitorinhibit

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