2. MAPK/ERK Pathway Autophagy Apoptosis
  3. JNK Autophagy Apoptosis Ferroptosis
  4. SP600125 (Standard)

SP600125 (Standard) is the analytical standard of SP600125. This product is intended for research and analytical applications. SP600125 is an orally active, reversible, and ATP-competitive JNK inhibitor with IC50s of 40, 40 and 90 nM for JNK1, JNK2 and JNK3, respectively. SP600125 is a potent ferroptosis inhibitor. SP600125 induces the transformation of bladder cancer cells from autophagy to apoptosis.

For research use only. We do not sell to patients.

SP600125 (Standard) Chemical Structure

SP600125 (Standard) Chemical Structure

CAS No. : 129-56-6

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Description
Molecular Weight

220.23

Formula

C14H8N2O
CAS No.
SMILES

O=C1C2=C3C(NN=C3C4=C1C=CC=C4)=CC=C2
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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SP600125 (Standard) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP600125 (Standard)129-56-6JNKAutophagyApoptosisFerroptosisc-Jun N-terminal kinasereversibleATP-competitivephosphorylationInhibitorinhibitorinhibit

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