5,6-trans-Vitamin D3  (Synonyms: 5,6-trans-Cholecalciferol; 5,6-trans-Colecalciferol; Cholecalciferol EP Impurity A)

5,6-trans-Vitamin D3 (5,6-trans-Cholecalciferol;5,6-trans-Colecalciferol) is a photoproduct of vitamin D3^[1]. Vitamin D3 is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

Normal human keratinocytes in the cultured human keratinocytes by determining their influence on ³H-thymidine incorporation into DNA.
5,6-trans-vitamin D3 only induces significant inhibition at 10^(-6) M. The dissociation constants of vitamin D receptor (VDR) for 5,6-trans-vitamin D3 is 560 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

384.64

C₂₇H₄₄O

22350-41-0

Solid

White to light yellow

O[C@@H]1C/C(C(CC1)=C)=C\C=C2[C@]3([H])CC[C@H]([C@H](C)CCCC(C)C)[C@@]3(C)CCC\2

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. T C Chen, et al. An evaluation of the biologic activity and vitamin D receptor binding affinity of the photoisomers of vitamin D3 and previtamin D3. J Nutr Biochem. 2000 May;11(5):267-72.  [Content Brief]