2. Apoptosis Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Ferroptosis Glutathione Peroxidase Reactive Oxygen Species (ROS)
  4. Ferroptosis inducer-11

Ferroptosis inducer-11 is a ferroptosis inducer. Ferroptosis inducer-11 exhibits potent cytotoxicity against HCT-116, NCM-60 and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM and 0.48 μM, respectively. Ferroptosis inducer-11 strongly suppresses GPX4 enzymatic activity with an IC50 of 1.86 μM. Ferroptosis inducer-11 induces ferroptosis, as well as increases intracellular lipid ROS, malondialdehyde (MDA), and Fe2+ levels, while decreasing glutathione (GSH) levels in colon cancer cells. Ferroptosis inducer-11 can be used for the study of colon cancer.

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Ferroptosis inducer-11

Ferroptosis inducer-11 Chemical Structure

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Ferroptosis inducer-11 Related Antibodies

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Description

Ferroptosis inducer-11 is a ferroptosis inducer. Ferroptosis inducer-11 exhibits potent cytotoxicity against HCT-116, NCM-60 and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM and 0.48 μM, respectively. Ferroptosis inducer-11 strongly suppresses GPX4 enzymatic activity with an IC50 of 1.86 μM. Ferroptosis inducer-11 induces ferroptosis, as well as increases intracellular lipid ROS, malondialdehyde (MDA), and Fe2+ levels, while decreasing glutathione (GSH) levels in colon cancer cells. Ferroptosis inducer-11 can be used for the study of colon cancer[1].

IC50 & Target[1]

GPX4

1.86 μM (IC50)

In Vitro

Ferroptosis inducer-11 (Compound 30) (0.25-1 μM, 24 h) shows potent inhibitory activity on colony formation of HCT-116 colon cancer cells[1].
Ferroptosis inducer-11 exhibits potent cytotoxicity against HCT-116, NCM-60 and HT-29 cells with IC50 values of 0.43 μM, 3.14 μM and 0.48 μM, respectively[1].
Ferroptosis inducer-11 (0.25-1 μM, 6-24 h) significantly increases lipid ROS levels in a time- and dose-dependent manner in HCT-116 cells[1].
Ferroptosis inducer-11 (0.25-1 μM, 12 h) dose-dependently elevates MDA levels, increases intracellular Fe2+ levels and reduces GSH levels in HCT-116 cells[1].
Ferroptosis inducer-11 shows potent GPX4 inhibitory activity, with an IC50 value of 1.86 μM[1].
Ferroptosis inducer-11 (0.25-1 μM, 6-24 h) downregulates GPX4 protein expression in a time- and dose-dependent manner in HCT-116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ferroptosis inducer-11 Related Antibodies

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.25, 0.5. 1 μM
Incubation Time: 6, 12, 24 h
Result: Downregulated GPX4 protein expression in a time- and dose-dependent manner in HCT-116 cells[1].
Molecular Weight

552.62

Formula

C30H36N2O8
SMILES

O=C(C1=CC[C@@]([C@@](CC1)(OC(C)=O)[C@@H]2[C@](/C=C/C=C(C)/C(N3CCN(C(C#C)=O)CC3)=O)(C)O4)(CC2)C4=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

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Purity & Documentation
References
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Ferroptosis inducer-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ferroptosis inducer-11Ferroptosis inducer11Ferroptosis inducer 11FerroptosisGlutathione PeroxidaseReactive Oxygen Species (ROS)ferroptosisROSHCT-116 cellsNCM-60 cellsHT-29 cellsMDAGSHcolon cancerInhibitorinhibitorinhibit

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