2. NF-κB
  3. Keap1-Nrf2
  4. BPK-29

BPK-29 is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 impairs the anchorage-independent growth of KEAP1-mutant cancer cells.

For research use only. We do not sell to patients.

BPK-29 Chemical Structure

BPK-29 Chemical Structure

CAS No. : 2143467-62-1

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Based on 1 publication(s) in Google Scholar

Other Forms of BPK-29:

BPK-29 Related Antibodies

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Description

BPK-29 is a specific ligand that disrupts the atypical orphan nuclear receptor NR0B1-protein (such RBM45 and SNW1) interactions by covalently modifying C274. BPK-29 impairs the anchorage-independent growth of KEAP1-mutant cancer cells[1].

In Vitro

BPK-29 substantially engages NR0B1 with good overall proteomic selectivity in KEAP1-mutant Non-Small Cell Lung Cancers[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BPK-29 Related Antibodies
Molecular Weight

470.00

Formula

C26H32ClN3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N(C1CCN(C(C2=CC=C(N3CCOCC3)C=C2)=O)CCC1)CC4=CC=CC=C4)CCl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 52 mg/mL (110.64 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1277 mL 10.6383 mL 21.2766 mL
5 mM 0.4255 mL 2.1277 mL 4.2553 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.4%

SDS (251 KB)

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1277 mL 10.6383 mL 21.2766 mL 53.1915 mL
5 mM 0.4255 mL 2.1277 mL 4.2553 mL 10.6383 mL
10 mM 0.2128 mL 1.0638 mL 2.1277 mL 5.3191 mL
15 mM 0.1418 mL 0.7092 mL 1.4184 mL 3.5461 mL
20 mM 0.1064 mL 0.5319 mL 1.0638 mL 2.6596 mL
25 mM 0.0851 mL 0.4255 mL 0.8511 mL 2.1277 mL
30 mM 0.0709 mL 0.3546 mL 0.7092 mL 1.7730 mL
40 mM 0.0532 mL 0.2660 mL 0.5319 mL 1.3298 mL
50 mM 0.0426 mL 0.2128 mL 0.4255 mL 1.0638 mL
60 mM 0.0355 mL 0.1773 mL 0.3546 mL 0.8865 mL
80 mM 0.0266 mL 0.1330 mL 0.2660 mL 0.6649 mL
100 mM 0.0213 mL 0.1064 mL 0.2128 mL 0.5319 mL
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BPK-29 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BPK-292143467-62-1BPK29BPK 29Keap1-Nrf2Inhibitorinhibitorinhibit

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