2. Cell Cycle/DNA Damage Apoptosis Anti-infection
  3. DNA/RNA Synthesis Apoptosis Antibiotic
  4. (±)-Dehydroaltenusin

(±)-Dehydroaltenusin, an antibiotic, is a selective eukaryotic DNA polymerase α (pol α) inhibitor with an IC50 of 0.68 μM. (±)-Dehydroaltenusin can be isolated from fungus Alternaria tenuis. (±)-Dehydroaltenusin competitively inhibits the DNA template primer (Ki: 0.23 μM) and non-competitively suppresses the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki: 0.18 μM). (±)-Dehydroaltenusin induces the cancer cell S-phase cycle arrest and apoptosis. (±)-Dehydroaltenusin can be used for cancers like human adenocarcinoma research.

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(±)-Dehydroaltenusin

(±)-Dehydroaltenusin Chemical Structure

CAS No. : 34279-44-2

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(±)-Dehydroaltenusin Related Antibodies

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Description

(±)-Dehydroaltenusin, an antibiotic, is a selective eukaryotic DNA polymerase α (pol α) inhibitor with an IC50 of 0.68 μM. (±)-Dehydroaltenusin can be isolated from fungus Alternaria tenuis. (±)-Dehydroaltenusin competitively inhibits the DNA template primer (Ki: 0.23 μM) and non-competitively suppresses the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki: 0.18 μM). (±)-Dehydroaltenusin induces the cancer cell S-phase cycle arrest and apoptosis. (±)-Dehydroaltenusin can be used for cancers like human adenocarcinoma research[1].

Molecular Weight

288.25

Formula

C15H12O6
CAS No.
SMILES

O=C(C(O)=C1)C=C(C2=CC(OC)=CC(O)=C23)C1(C)OC3=O
Structure Classification
Initial Source

Penicillium verruculosum
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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(±)-Dehydroaltenusin Related Classifications

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  • Do most proteins show cross-species activity?

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Keywords:

(±)-Dehydroaltenusin34279-44-2DNA/RNA SynthesisApoptosisAntibioticInhibitorDNA polymerase αPol αAlternaria tenuisHuman adenocarcinomainhibitorinhibit

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