2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker DNA/RNA Synthesis Topoisomerase
  4. MGB1Y

MGB1Y is a noncovalent DNA minor groove binder (MGB). MGB1Y potently inhibits cancer cells proliferation and topoisomerase I activity. MGB1Y downregulates their breast cancer-related genes in MCF7 and MDA-MB-231 cells. MGB1Y has a broad-spectrum anticancer activity, such as breast cancer, colon cancer, and leukemia.

For research use only. We do not sell to patients.

MGB1Y

MGB1Y Chemical Structure

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MGB1Y Related Antibodies

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Topoisomerase Topo I Topo II

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Description

MGB1Y is a noncovalent DNA minor groove binder (MGB). MGB1Y potently inhibits cancer cells proliferation and topoisomerase I activity. MGB1Y downregulates their breast cancer-related genes in MCF7 and MDA-MB-231 cells. MGB1Y has a broad-spectrum anticancer activity, such as breast cancer, colon cancer, and leukemia[1].

IC50 & Target[1]

Topoisomerase I

 

Molecular Weight

603.76

Formula

C30H33N7O3S2
SMILES

O=C(C1=C(C(C)C)SC(NC(C2=CC(NC(C3=CC=C(C#CC4=CSC=N4)C=C3)=O)=CN2C)=O)=N1)NCCCN(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MGB1Y Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MGB1YDNA Alkylator/CrosslinkerDNA/RNA SynthesisTopoisomeraseMinor groove binderMGBDNATopoisomerase IMCF7 cellsMDA-MB-231 cellsAnticancerBreast cancerColon cancerLeukemiaInhibitorinhibitorinhibit

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