2. Apoptosis
  3. MDM-2/p53
  4. PNC-27

PNC-27, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 is an anticancer peptide. PNC-27 can be used in acute myeloid leukemia research.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PNC-27 Chemical Structure

PNC-27 Chemical Structure

CAS No. : 1159861-00-3

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Based on 1 publication(s) in Google Scholar

Other Forms of PNC-27:

PNC-27 Related Antibodies

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  • Biological Activity

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Description

PNC-27, a chimeric p53-penetratin peptide binds to HDM-2 in a p53 peptide-like structure, induces selective membrane-pore formation and leads to cancer cell lysis. PNC-27 is an anticancer peptide. PNC-27 can be used in acute myeloid leukemia research[1][2][3].

In Vitro

PNC-27 (50 μg/mL; 0-3 h) induces cancer cell death[1].
PNC-27 (50 μg/mL; 15 min) binds to cell membrane-bound HDM-2 in A2058 and MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PNC-27 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: MIA-PaCa-2 cells
Concentration: 50 μg/mL
Incubation Time: 0-3 hours
Result: Induced 100% cell death in 90 min.

Immunofluorescence[1]

Cell Line: A2058 and MCF-7 cells
Concentration: 50 μg/mL
Incubation Time: 15 min
Result: Showed colocalization of PNC-27 with HDM-2 in the cancer cell membrane.
In Vivo

PNC-27 (intraperitoneal injection; 40 mg/kg; once daily; 2-3 w) shows anti-leukemia activity in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MllPTD/WT/Flt3ITD/ITD AML mice[2]
Dosage: 40 mg/kg
Administration: Intraperitoneal injection; 40 mg/kg; once daily; 2 or 3 weeks
Result: Reduced AML engraftment and prolonged survival.
Molecular Weight

4031.73

Formula

C188H293N53O44S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

PPLSQETFSDLWKLLKKWKMRRNQFWVKVQRG
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (24.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2480 mL 1.2402 mL 2.4803 mL
5 mM 0.0496 mL 0.2480 mL 0.4961 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2480 mL 1.2402 mL 2.4803 mL 6.2008 mL
5 mM 0.0496 mL 0.2480 mL 0.4961 mL 1.2402 mL
10 mM 0.0248 mL 0.1240 mL 0.2480 mL 0.6201 mL
15 mM 0.0165 mL 0.0827 mL 0.1654 mL 0.4134 mL
20 mM 0.0124 mL 0.0620 mL 0.1240 mL 0.3100 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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PNC-27 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PNC-271159861-00-3PNC27PNC 27MDM-2/p53anti-tumor activityacute myeloid leukemiaMIA-PaCa-2A2058MCF-7Inhibitorinhibitorinhibit

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