2. Stem Cell/Wnt Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Wnt β-catenin PPAR CDK
  4. CCT036477

CCT036477 is a Wnt/β-catenin pathway inhibitor. CCT036477 blocks transcription at β-catenin without altering its levels. CCT036477 inhibits proliferation of various cancer cells, development of embryos, and expression of Wnt target genes (PPARδ, Cyclin D1, TCF4, and ID2).

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CCT036477 Chemical Structure

CCT036477 Chemical Structure

CAS No. : 305372-78-5

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Based on 1 publication(s) in Google Scholar

CCT036477 Related Antibodies

Top Publications Citing Use of Products

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Description

CCT036477 is a Wnt/β-catenin pathway inhibitor. CCT036477 blocks transcription at β-catenin without altering its levels. CCT036477 inhibits proliferation of various cancer cells, development of embryos, and expression of Wnt target genes (PPARδ, Cyclin D1, TCF4, and ID2)[1][2].

Molecular Weight

347.84

Formula

C21H18ClN3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(NC1=C2C=CC=C1)=C2C(C3=CC=C(C=C3)Cl)NC4=NC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (287.49 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8749 mL 14.3744 mL 28.7488 mL
5 mM 0.5750 mL 2.8749 mL 5.7498 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8749 mL 14.3744 mL 28.7489 mL 71.8721 mL
5 mM 0.5750 mL 2.8749 mL 5.7498 mL 14.3744 mL
10 mM 0.2875 mL 1.4374 mL 2.8749 mL 7.1872 mL
15 mM 0.1917 mL 0.9583 mL 1.9166 mL 4.7915 mL
20 mM 0.1437 mL 0.7187 mL 1.4374 mL 3.5936 mL
25 mM 0.1150 mL 0.5750 mL 1.1500 mL 2.8749 mL
30 mM 0.0958 mL 0.4791 mL 0.9583 mL 2.3957 mL
40 mM 0.0719 mL 0.3594 mL 0.7187 mL 1.7968 mL
50 mM 0.0575 mL 0.2875 mL 0.5750 mL 1.4374 mL
60 mM 0.0479 mL 0.2396 mL 0.4791 mL 1.1979 mL
80 mM 0.0359 mL 0.1797 mL 0.3594 mL 0.8984 mL
100 mM 0.0287 mL 0.1437 mL 0.2875 mL 0.7187 mL
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CCT036477 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCT036477305372-78-5CCT 036477CCT-036477Wntβ-cateninPPARCDKBeta cateninPeroxisome proliferator-activated receptorsCyclin dependent kinaseCRPCMantle cell lymphomaMCLInhibitorinhibitorinhibit

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