2. Protein Tyrosine Kinase/RTK Apoptosis JAK/STAT Signaling PI3K/Akt/mTOR
  3. VEGFR Apoptosis EGFR mTOR
  4. 4-TCPA

4-TCPA is a potent VEGFR2 inhibitor. 4-TCPA induces apoptosis and cell cycle arrest, likely through inhibition of VEGFR2 and EGFR signaling with additional effects on the mTOk pathway. 4-TCPA can inhibit the vitality and proliferation of various cancer cell lines. 4-TCPA can be used for the study of cancers such as lung cancer, breast cancer and leukemia.

For research use only. We do not sell to patients.

4-TCPA Chemical Structure

4-TCPA Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

4-TCPA Related Antibodies

Top Publications Citing Use of Products

View All VEGFR Isoform Specific Products:

View All Isoforms
VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

View All EGFR Isoform Specific Products:

View All Isoforms
EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

View All mTOR Isoform Specific Products:

View All Isoforms
mTOR mTORC1 mTORC2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

4-TCPA is a potent VEGFR2 inhibitor. 4-TCPA induces apoptosis and cell cycle arrest, likely through inhibition of VEGFR2 and EGFR signaling with additional effects on the mTOk pathway. 4-TCPA can inhibit the vitality and proliferation of various cancer cell lines. 4-TCPA can be used for the study of cancers such as lung cancer, breast cancer and leukemia[1].

IC50 & Target[1]

VEGFR2

 

mTOR

 

In Vitro

4-TCPA (0-200 μM, 72 h) 4-TCPA exhibits inhibitory activity with IC50s of 35.70 μM for A549, 19.50 μM for MCF7, 5.95 μM for K562 and 135.2 μM for HFF2 cells[1].
4-TCPA (5.95-35.70 μM, 72 h) activates the mitochondrial pathway with varying sensitivity, causing apoptotic cell death in K562, MCF7 and A549 cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4-TCPA Related Antibodies

Cell Proliferation Assay[1]

Cell Line: K562, MCF7, A549 and HFF2 cells
Concentration: 5, 10, 15, 20, 30, 40, 50, 60, 70, 80, 90, 100, 150, 200 μM
Incubation Time: 72 h
Result: Demonstrated a dose- and time-dependent decrease in the viability and proliferation of cell lines.
Exhibited nearly twofold more activity in producing cytotoxic effects on the cancer cell line.
Was somewhat hazardous to the regular HFF2 cell line.

Apoptosis Analysis[1]

Cell Line: K562, MCF7, A549 cells
Concentration: 5.95, 19.50, 35.70 μM
Incubation Time: 72 h
Result: The early and late apoptosis in all cell lines increased significantly with time.
More than 40% of the treated cells underwent apoptosis.
Increased the activity of caspase 3/7 in a time-dependent manner.

RT-PCR[1]

Cell Line: K562, MCF7, A549 and HFF2 cells
Concentration: 5, 10, 15, 20, 30, 40, 50, 60, 70, 80, 90, 100, 150, 200 μM
Incubation Time: 72 h
Result: Decreased the levels of EGFR, VEGFR2 and mTOR in A549.
Decreased the levels of EGFR, VEGFR2, mTOR, MAPK-1 and PIK3CA in MCF7.
Decreased the levels of EGFR, VEGFR2, mTOR, MAPK-1 and Akt in K562.
Molecular Weight

541.99

Formula

C25H28ClN7O5
SMILES

O=C(NC1=CC=C(Cl)C=C1)CN2N=NC(CNC3=C4C=C(OCCOC)C(OCCOC)=CC4=NC=N3)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

4-TCPA Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-TCPAVEGFRApoptosisEGFRmTORVascular endothelial growth factor receptorEpidermal growth factor receptorErbB-1HER1Mammalian target of RapamycinQuinazolineCancer cellVEGFR2Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
4-TCPA
Cat. No.:
HY-175220
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.