2. Metabolic Enzyme/Protease Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. Lipoxygenase β-catenin STAT Apoptosis
  4. ALOX5 stabilizer-1

ALOX5 stabilizer-1 is an arachidonate 5-lipoxygenase (ALOX5) stabilizer with a Kd of 7.26 μM. ALOX5 stabilizer-1 inhibits β-catenin protein levels and then suppresses STAT3 signal pathway. ALOX5 stabilizer-1 induces lung cancer cells apoptosis, inhibited cell migration and proliferation. ALOX5 stabilizer-1 can used for the study of non-small cell lung cancer (NSCLC).

For research use only. We do not sell to patients.

ALOX5 stabilizer-1

ALOX5 stabilizer-1 Chemical Structure

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ALOX5 stabilizer-1 Related Antibodies

Top Publications Citing Use of Products

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5-LOX 12-LOX 15-LOX

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STAT3 STAT5 STAT6 STAT1

  • Biological Activity

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Description

ALOX5 stabilizer-1 is an arachidonate 5-lipoxygenase (ALOX5) stabilizer with a Kd of 7.26 μM. ALOX5 stabilizer-1 inhibits β-catenin protein levels and then suppresses STAT3 signal pathway. ALOX5 stabilizer-1 induces lung cancer cells apoptosis, inhibited cell migration and proliferation. ALOX5 stabilizer-1 can used for the study of non-small cell lung cancer (NSCLC)[1].

IC50 & Target[1]

STAT3

 

In Vitro

ALOX5 stabilizer-1 (Compound 10d) (72 h) inhibits NCI-H820 cell proliferation with an IC50 of 0.11 μM and shows weaker toxicity against 3T3 cells with an IC50 of 0.48 μM [1].
ALOX5 stabilizer-1 (0-0.2 μM, 10 d) inhibits colony formation of with NCI-H820 cells a dose-dependent manner[1].
ALOX5 stabilizer-1 (0-0.2 μM, 48 h) inhibits NCI-H820 cell migration and induces cell apoptosis[1].
ALOX5 stabilizer-1 (0-0.2 μM, 48 h) directly targets ALOX5 protein and enhances protein stability, then inhibites β-catenin protein levels and eventually suppressed STAT3 signal pathway in NCI-H820 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALOX5 stabilizer-1 Related Antibodies

Cell Migration Assay [1]

Cell Line: NCI-H820 cells
Concentration: 0, 0.05, 0.1 and 0.2 μM
Incubation Time: 48 h
Result: Obviously inhibited migration in dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: NCI-H820 cells
Concentration: 0, 0.05, 0.1 and 0.2 μM
Incubation Time: 48 h
Result: Increased the percentage of apoptosis.

Western Blot Analysis[1]

Cell Line: NCI-H820 cells
Concentration: 0, 0.02, 0.05, 0.1 and 0.2 μM
Incubation Time: 48 h
Result: Significantly decreased the expression of anti-apoptotic proteins Bcl-2 and Mcl-1 while increased the expression of apoptosis-related protein Bax in a dose-dependent manner.
Was directly bound to ALOX5 protein.
Inhibited both the nuclear translocation and protein levels of β-catenin.
Reduced the levels of STAT3 and p-STAT3.
Molecular Weight

552.62

Formula

C32H32N4O5
SMILES

C=C1C(O[C@H]2[C@H]1CC/C(CN3C=C(N=N3)COC4=CC=C(C=C4)C(/C=C/C5=CC=CN=C5)=O)=C\CC[C@]6(O[C@@H]26)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ALOX5 stabilizer-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALOX5 stabilizer-1Lipoxygenaseβ-cateninSTATApoptosisLOXBeta cateninALOX5Anti-cancer activityChalconeParthenolideInhibitorinhibitorinhibit

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