2. Neuronal Signaling Apoptosis
  3. Amyloid-β MDM-2/p53 Apoptosis
  4. Quinovic acid

Quinovic acid is triterpene. Quinovic acid can ameliorate the Amyloid-β burden, p53 expression and cholesterol accumulation by deterring the oxidative stress through upregulating the Nrf2/HO-1 pathway. Quinovic acid can induce cancer cells apoptosis by upregulating death receptor 5 (DR5). Quinovic acid can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as lung cancer and Alzheimer’s disease (AD).

For research use only. We do not sell to patients.

Quinovic acid

Quinovic acid Chemical Structure

CAS No. : 465-74-7

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Based on 1 publication(s) in Google Scholar

Quinovic acid Related Antibodies

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Description

Quinovic acid is triterpene. Quinovic acid can ameliorate the Amyloid-β burden, p53 expression and cholesterol accumulation by deterring the oxidative stress through upregulating the Nrf2/HO-1 pathway. Quinovic acid can induce cancer cells apoptosis by upregulating death receptor 5 (DR5). Quinovic acid can be used for the researches of cancer, inflammation, metabolic and neurological disease, such as lung cancer and Alzheimer’s disease (AD)[1][2].

In Vitro

Quinovic acid (5-115 μM, 24 h) shows low cytotoxicity and alleviates oligomeric Aβ (AβO)-induced cell death in SH-SY5Y cells[1].
Quinovic acid (85 μM, 24 h) downregulates AβO-induced expressions of p53 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) in SH-SY5Y cells[1].
Quinovic acid (QA) (5-40 μM, 24-72 h) inhibits the proliferation and viability of A549, H1299, MCF-7 and MDA-MB-231 cells[2].
Quinovic acid (QA) (25-35 μM, 24 h) induces apoptosis in MDA-MB-231 and A549 cells[2].
Quinovic acid (25 μM, 4-24 h) upregulates the mRNA and protein levels of death receptor 5 (DR5) in A549, MCF-7, and MDA-MB-231 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Quinovic acid Related Antibodies

Western Blot Analysis[1]

Cell Line: MDA-MB-231 and A549 cells
Concentration: 25, 30 and 35 μM
Incubation Time: 24 h
Result: Reduced procaspase 3 and 8 levels.
Increased cleaved PARP levels.
In Vivo

Quinovic acid (50 mg/kg, i.p., every other day for 3 weeks) significantly ameliorates Aβ(1-42)-induced pathological damage in C57BL/6J mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice treated with Aβ(1-42)[1]
Dosage: 50 mg/kg
Administration: Intraperitoneally injection, every other day for 3 weeks
Result: Reduced Aβ oligomers, monomers, and BACE1 expression in cortex/hippocampus and decreased Aβ burden.
Downregulated p53 and HMGCR expressions and reduced total and free cholesterol levels.
Activated the Nrf2/HO-1 pathway, reduced ROS levels and restored GSH/GSSG ratio.
Downregulated GFAP, Iba-1, p-NF-κB, and IL-1β.
Downregulated Bax, cytochrome c, cleaved caspase-3; upregulates Bcl-2 and upregulated PSD-95 and synaptophysin.
Enhanced cognitive ability.
Molecular Weight

486.68

Formula

C30H46O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC([C@@]12C([C@@]3([H])[C@@](CC2)(CC[C@H]([C@@H]3C)C)C(O)=O)=CC[C@@]4([H])[C@]1(CC[C@]5([H])[C@@]4(CC[C@@H](C5(C)C)O)C)C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Quinovic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Quinovic acid465-74-7Amyloid-βMDM-2/p53Apoptosisβ-amyloid peptideAβAbetaTriterpenep53CholesterolOxidative stressNrf2/HO-1DR5Lung cancerBreast cancerAlzheimer’s diseaseA549H1299MCF-7MDA-MB-231Inhibitorinhibitorinhibit

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