2. PROTAC Epigenetics
  3. Molecular Glues Epigenetic Reader Domain
  4. IBG1

IBG1 is a molecular glue degrader targeting BRD2 and BRD4 (DC50: 0.15 nM). IBG1 has no significant degradation effect on its paralogue BRD3. IBG1 can inhibit the growth of cancer cells and can be used in tumor research. (Pink: BRD2/BRD4 Ligand (HY-111139); Black: Linker; Blue: DCAF15 ligand-1 (HY-W037495)).

For research use only. We do not sell to patients.

IBG1

IBG1 Chemical Structure

CAS No. : 2684292-71-3

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Based on 1 publication(s) in Google Scholar

IBG1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

IBG1 is a molecular glue degrader targeting BRD2 and BRD4 (DC50: 0.15 nM). IBG1 has no significant degradation effect on its paralogue BRD3. IBG1 can inhibit the growth of cancer cells and can be used in tumor research. (Pink: BRD2/BRD4 Ligand (HY-111139); Black: Linker; Blue: DCAF15 ligand-1 (HY-W037495))[1][2].

IC50 & Target[1]

BRD2

 

BRD4

0.15 nM (DC50)

In Vitro

IBG1 (0.1-1000 nM; 6 h) can effectively degrade BRD2 and BRD4 in HEK293 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IBG1 Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 0.1, 1, 10, 100, and 1000 nM
Incubation Time: 6 h
Result: Reduced the levels of BRD2 and BRD4.
Molecular Weight

822.95

Formula

C44H38N8O5S2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

CC1=C(C)SC2=C1C(C3=CC=C(C4=CC=C(C=C4)C(NCC5=CC=C(C=C5)S(NC6=C7C(C(C#N)=CN7)=C(C=C6)C)(=O)=O)=O)C=C3)=N[C@@H](CC(OC)=O)C8=NN=C(C)N28
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (121.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2151 mL 6.0757 mL 12.1514 mL
5 mM 0.2430 mL 1.2151 mL 2.4303 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2151 mL 6.0757 mL 12.1514 mL 30.3785 mL
5 mM 0.2430 mL 1.2151 mL 2.4303 mL 6.0757 mL
10 mM 0.1215 mL 0.6076 mL 1.2151 mL 3.0379 mL
15 mM 0.0810 mL 0.4050 mL 0.8101 mL 2.0252 mL
20 mM 0.0608 mL 0.3038 mL 0.6076 mL 1.5189 mL
25 mM 0.0486 mL 0.2430 mL 0.4861 mL 1.2151 mL
30 mM 0.0405 mL 0.2025 mL 0.4050 mL 1.0126 mL
40 mM 0.0304 mL 0.1519 mL 0.3038 mL 0.7595 mL
50 mM 0.0243 mL 0.1215 mL 0.2430 mL 0.6076 mL
60 mM 0.0203 mL 0.1013 mL 0.2025 mL 0.5063 mL
80 mM 0.0152 mL 0.0759 mL 0.1519 mL 0.3797 mL
100 mM 0.0122 mL 0.0608 mL 0.1215 mL 0.3038 mL
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IBG1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IBG12684292-71-3IBG 1IBG-1Molecular GluesEpigenetic Reader DomainBRD4cancerHEK293 cellsInhibitorinhibitorinhibit

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