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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W002199
    6:2 Fluorotelomer alcohol

    6:2 FTOH; 1H,1H,2H,2H-Perfluoro-1-octanol; 2-(Perfluorohexyl)ethanol

    		 Bacterial Infection
    6:2 Fluorotelomer alcohol (6:2 FTOH) is a short-chain perfluoroalkyl substance (PFAS) in polymer PFAS that can be degraded by microbial action, significantly affecting the structure of bacterial communities in sediments and causing changes in the richness and diversity of the bacterial communities .
    6:2 Fluorotelomer alcohol
  • HY-34887
    Acridone-4-carboxylic acid

    		Drug Derivative Others
    Acridone-4-carboxylic acid (ACA) (Compound 2c) is a heme-interacting acridone derivatives that prevents free heme-mediated protein oxidation and degradation. Acridone-4-carboxylic acid inhibits protein carbonyl formation with an IC50 of 43 μM .
    Acridone-4-carboxylic acid
  • HY-172767
    STAT3-D11-PROTAC-VHL

    		PROTACs STAT Apoptosis Cancer
    STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting Signal Transducer and Activator of Transcription 3 (STAT3). STAT3-D11-PROTAC-VHL exhibits anti-tumor activity with IC50 values of 1335 nM and 1973 nM against HeLa and MCF-7 cells, respectively. STAT3-D11-PROTAC-VHL binds to the DNA-binding domain of STAT3 and recruits the E3 ligase VHL to form a ternary complex, leading to the ubiquitination of STAT3 and subsequent degradation by the proteasome. STAT3-D11-PROTAC-VHL also inhibits tumor cell growth, induces cell cycle arrest and apoptosis, and suppresses tumor immune evasion .
    STAT3-D11-PROTAC-VHL
  • HY-N2406
    Dihydrocaffeic acid
    2 Publications Verification

    3,4-Dihydroxy-benzenepropanoic acid

    		 p38 MAPK Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Inflammation/Immunology
    Dihydrocaffeic acid is a microbial metabolite of flavonoids. Dihydrocaffeic acid scavenges intracellular ROS and increases nitric oxide synthase activity. Dihydrocaffeic acid reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Dihydrocaffeic acid has antioxidant, anti-inflammatory and anti-cartilage degradation activities .
    Dihydrocaffeic acid
  • HY-P99406
    Petosemtamab

    MCLA 158

    		 EGFR Cancer
    Petosemtamab (MCLA 158) is an anti- EGFR (Kd: 0.22 nM) and anti-LGR5 (Kd: 0.86 nM) monoclonal antibody (mAb). Petosemtamab leads to EGFR signaling blockade and receptor degradation in LGR5+ cancer cells. Petosemtamab can be used in the research of solid tumors, such as head and neck squamous cell carcinoma (HNSCC), metastatic colorectal cancer (CRC) .
    Petosemtamab
  • HY-176489
    PROTAC pan-KRAS degrader-1

    		PROTACs Ras Cancer
    PROTAC pan-KRAS degrader-1 is a pan-KRAS PROTAC degrader for degrading different KRAS mutation types, such as G12D, G12C, G12V, and G13D. PROTAC pan-KRAS degrader-1 potently degrades KRAS mutation (G12D) in AGS cells, with a DC50 of 1.1 nM, Dmax of 95%. PROTAC pan-KRAS degrader-1 can be used to search diseases caused by KRAS mutation or amplification, especially cancers such as breast cancer, bladder cancer, gastric cancer, etc . Pink: pan-KRAS ligand (HY-176490); Blue: VHL ligase ligand (HY-170353); Black: linker (HY-176491);
    PROTAC pan-KRAS degrader-1
  • HY-174405
    PROTAC PDE4 degrader-1

    		PROTACs Phosphodiesterase (PDE) TNF Receptor Interleukin Related Inflammation/Immunology
    PROTAC PDE4 degrader-1 (Compound 9m) is a selective and orally active PDE4 PROTAC degrader with a DC50 of 41.98 μM. PROTAC PDE4 degrader-1 potently inhibits the secretion of pro-inflammatory cytokines such as TNF-α and IL-6. PROTAC PDE4 degrader-1 significantly alleviates pulmonary inflammation in LPS (HY-D1056)-induced acute lung injury (ALI) mice Model . Pink: PDE4 ligand (HY-174410); Blue: CRBN ligase ligand (HY-10984); Black: linker
    PROTAC PDE4 degrader-1
  • HY-162538
    LC-MI-3

    		NF-κB IRAK PROTACs Inflammation/Immunology
    LC-MI-3 is an orally active and potent interleukin-1 receptor-associated kinase 4 (IRAK4) PROTAC degrader, with a DC50 of 47.3 nM. LC-MI-3 effectively inhibits the activation of downstream NF-κB signaling. LC-MI-3 can be used for the research of acute and chronic inflammatory skin. (Blue: VHL ligand, Black: linker, Pink: CRBN ligand (HY-14658)) .
    LC-MI-3
  • HY-P3171
    Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13)

    		Biochemical Assay Reagents Others
    Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) is a melanotropin cyclic peptide. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) ultraprolongs melanotropic activity in frog and lizard skin model with great agonisim. Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13) exhibits a complete resistance to tryptic degradation .
    Acetyl-(Cys4,D-Phe7,Cys10)-a-MSH (4-13)
  • HY-156292
    IHMT-EZH2-426

    		Histone Methyltransferase Cancer
    IHMT-EZH2-426 (compound 38) is an effective covalent EZH2 degrader, with IC50 values of 1.3 nM, 1.2 nM, and 1.7-3.5 nM for EZH2 wild type, EZH2-A687V, and EZH2-Y641F/Y641N/Y641S, respectively. IHMT-EZH2-426 reduces H3K27me3 and EZH2 levels and shows effective anti-proliferative effects in B-cell lymphoma and TNBC cell lines.
    IHMT-EZH2-426
  • HY-153880
    KRAS degrader-1

    		PROTACs Ras Cancer
    KRAS degrader-1 (compound 1) is a potent KRAS degrader. KRAS degrader-1 target specific proteins for degradation through the autophagy-lysosomal degradation pathway .
    KRAS degrader-1
  • HY-N2406R
    Dihydrocaffeic acid (Standard)

    3,4-Dihydroxy-benzenepropanoic acid (Standard)

    		 Reference Standards p38 MAPK Endogenous Metabolite Reactive Oxygen Species (ROS) NO Synthase Inflammation/Immunology
    Ditalimfos (Standard) is the analytical standard of Ditalimfos. This product is intended for research and analytical applications. Ditalimfos is an organophosphate fungicide. Ditalimfos is mainly used in agriculture to control fungal diseases of crops. Ditalimfos can be used for fungal resistance studies and risk assessment of residues in the environment .
    Dihydrocaffeic acid (Standard)
  • HY-178161
    HDAC degrader-2

    		HDAC Apoptosis Cancer
    HDAC degrader-2 is a selective HDAC degrader with a DC50 values of 2.55 μM against HDAC1. HDAC degrader-2 effectively induces the degradation of HDAC1 and HDAC2, but has no significant effect on the degradation of HDAC3, 4, 6 and 8. HDAC degrader-2 exerts potent antiproliferative effects against MM.1S and MCF-7 cells. HDAC degrader-2 induces apoptosis in myeloma cells. HDAC degrader-2 can be used for the study of myeloma .
    HDAC degrader-2
  • HY-168530
    PDL1 degrader-1

    		PD-1/PD-L1 Cancer
    PDL1 degrader-1 (compound PMT-O9-1A) is a potent PD-L1 degrader. PDL1 degrader-1 decreases the protein expression of PD-L1. PDL1 degrader-1 shows cytotoxicity. PDL1 degrader-1 shows anticancer activity .
    PDL1 degrader-1
  • HY-169278
    PROTAC SMARCA2 degrader-26

    		Epigenetic Reader Domain PROTACs Cancer
    PROTAC SMARCA2 degrader-26 (compound 45) is a potent SMARCA2 PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity .
    PROTAC SMARCA2 degrader-26
  • HY-147108
    Mitochondria degrader-1

    		Mitochondrial Metabolism Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Mitochondria degrader-1 (example 5) is a potent mitochondria degrader. Mitochondria degrader-1 induces the degradation of the injured mitochondria by the autophagy mechanism. Mitochondria degrader-1 can be used for the research of neurodegenerative disease, cancer, inflammatory disease, age-related disease, metabolic disease, mitochondrial disease or Down's disease .
    Mitochondria degrader-1
  • HY-122828
    PROTAC BTK Degrader-2

    		PROTACs Btk Others
    PROTAC BTK Degrader-2 is a potent BTK PROTAC degrader. PROTAC BTK Degrader-2 effectively reduces BTK protein levels .
    PROTAC BTK Degrader-2
  • HY-152145
    PROTAC SOS1 degrader-3

    		PROTACs Ras Cancer
    PROTAC SOS1 degrader-3 is a potent PROTAC SOS1 degrader. PROTAC SOS1 degrader-3 effectively targeted SOS1 for degradation through the ubiquitin-proteasome system .
    PROTAC SOS1 degrader-3
  • HY-128838A
    (rel)-PROTAC ERRα Degrader-1
    1 Publications Verification

    		 PROTACs Estrogen Receptor/ERR Others
    (rel)-PROTAC ERRα Degrader-1 is a relative configuration of PROTAC ERRα Degrader-1. PROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader .
    (rel)-PROTAC ERRα Degrader-1
  • HY-175810
    GSPT1 degrader-8

    		Molecular Glues Cancer
    GSPT1 degrader-8 is a potent and orally active G1 to S phase transition 1 (GSPT1) molecular glue degrader. GSPT1 degrader-8 induces GSPT1 degradation and inhibits tumor growth. GSPT1 degrader-8 can be used for the research of cancer, such as breast cancer .
    GSPT1 degrader-8
  • HY-177559
    NEK7 degrader-2

    		NEKs Interleukin Related NOD-like Receptor (NLR) Inflammation/Immunology
    NEK7 degrader-2 (Compound 25) is a NEK7 degrader. NEK7 degrader-2 shows dose-dependent NEK7 degradation ability in human PBMC-derived macrophages. NEK7 degrader-2 reduce the release level of pro-inflammatory cytokines IL-1β induced by NLRP3 inflammasome activation. NEK7 degrader-2 can be used for the study of inflammatory diseases .
    NEK7 degrader-2
  • HY-173327
    BRD4 degrader-6

    		PROTACs Epigenetic Reader Domain Cancer
    BRD4 degrader-6 is a dimeric BDR4 PROTAC degrader (DC50: < 0.1 μM). BRD4 degrader-6 promotes the ubiquitination and degradation of BDR4 and has anticancer activity .
    BRD4 degrader-6
  • HY-162014
    WDR5 degrader-1

    		PROTACs WDR5 Cancer
    WDR5 degrader-1 (compound 25) is a cereblon (CRBN)-recruiting WDR5 degrader. WDR5 degrader-1 selectively degraded WDR5 over the CRBN neo-substrate IKZF1 .
    WDR5 degrader-1
  • HY-153674
    PROTAC SOS1 degrader-4

    		SOS1 PROTACs Ras Cancer
    PROTAC SOS1 degrader-4 (compound 10) is a potent SOS1 degrader. PROTAC SOS1 degrader-4 shows antiproliferative activity .
    PROTAC SOS1 degrader-4
  • HY-139185
    PROTAC ERRα Degrader-3
    1 Publications Verification

    		 PROTACs Estrogen Receptor/ERR Cancer
    PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on von Hippel-Lindau ligand. PROTAC ERRα Degrader-3 is capable of specifically degrading ERRα protein by >80% at a concentration of 30 nM. PROTAC ERRα Degrader-3 is inactive against ERRβ and ERRγ proteins .
    PROTAC ERRα Degrader-3
  • HY-152154
    Nampt degrader-2

    		PROTACs NAMPT Cancer
    Nampt degrader-2 is a fluorescent PROTAC, which efficiently degrades NAMPT with an IC50 of 41.9 nM. Nampt degrader-2 binds to NAMPT and VHL to form a ternary complex and subsequently induced NAMPT degradation via ubiquitin-proteasome system (UPS). Nampt degrader-2 leads to significant reduction of NAD + and exerts potent antitumor activities .
    Nampt degrader-2
  • HY-145159
    SHP2 protein degrader-1

    		SHP2 PROTACs Phosphatase Apoptosis Cancer
    SHP2 protein degrader-1 is a potent allosteric inhibitor of SHP2. SHP2 protein degrader-1 induces SHP2 degradation and cell apoptosis. SHP2 protein degrader-1 has the potential for researching SHP2 related diseases .
    SHP2 protein degrader-1
  • HY-174238
    GSPT1 degrader-7

    		Molecular Glues Cancer
    GSPT1 degrader-7 (Example 43) is a molecular glue degrader targeting GSPT1. GSPT1 degrader-7 has an EC50 of 0.2 nM in DF15 multiple myeloma cells. GSPT1 degrader-7 can be used in the study of cancer .
    GSPT1 degrader-7
  • HY-158345
    PROTAC VHL-type degrader-1

    		PROTACs Cancer
    PROTAC VHL-type degrader-1 (compound 9b) is a VHL-type PROTAC degrader. PROTAC VHL-type degrader-1 induces ATM degradation synergistically enhancing the efficacy of ATR inhibitor AZD6738 .
    PROTAC VHL-type degrader-1
  • HY-176526
    BTK degrader-1 intermediate

    		Drug Intermediate Btk Cancer
    BTK degrader-1 intermediate (compound 5) is an intermediate for the synthesis of BTK degrader-1 (HY-163295). BTK degrader-1 can be used as an ADC toxin to synthesize antibody-drug conjugate (ADC) .
    BTK degrader-1 intermediate
  • HY-169273
    PROTAC SMARCA2 degrader-22

    		PROTACs SWI/SNF Complex Cancer
    PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader for SMARCA2 with a degradation efficacy of 94% at 100 nM. PROTAC SMARCA2 degrader-22 inhibits the proliferation of cell A549 with an EC50 < 250 nM .
    PROTAC SMARCA2 degrader-22
  • HY-162331
    STING Degrader-1

    		Molecular Glues STING Inflammation/Immunology Cancer
    STING Degrader-1 (compound 2), a molecular glue, is a potent STING degrader that covalently binds to STING and E3 ligase. STING Degrader-1 exhibits a "hook effect", that degrades 75% STING protein at 10 μM, and degrades ca. 30% STING protein at 30 μM .
    STING Degrader-1
  • HY-169270
    PROTAC SMARCA2 degrader-19

    		Epigenetic Reader Domain PROTACs Cancer
    PROTAC SMARCA2 degrader-19 (Compound 46) is a PROTAC degrader for SMARCA2, that degrades SMARCA2 in cell A549 and MV411 with a DC50 < 100 nM. PROTAC SMARCA2 degrader-19 degrades SMARCA4 in cell MV411 with a DC50 > 1000 nM .
    PROTAC SMARCA2 degrader-19
  • HY-175463
    LCK degrader-2

    		Molecular Glues Src Cancer
    LCK degrader-2 (Compound 17) is a Lck Molecular glue degrader. LCK degrader-2 can be used for cancers like acute lymphoblastic leukemia (ALL) research .
    LCK degrader-2
  • HY-149964
    PROTAC CDK9 degrader-7

    		PROTACs CDK Cancer
    PROTAC CDK9 degrader-7 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-7 mediates CDK9 degradation via the proteasome .
    PROTAC CDK9 degrader-7
  • HY-168965
    BTK ligand 15

    		Ligands for Target Protein for PROTAC Others
    BTK ligand 15 is the target protein ligand of PROTAC BTK Degrader-13 (HY-168963). PROTAC BTK Degrader-13 can selectively degrade BTK .
    BTK ligand 15
  • HY-159610
    GSPT1 degrader-10

    		Molecular Glues Cancer
    GSPT1 degrader-10 (compound A) is a cereblon-based molecular glue degrader of GSPT1 with more than 95% degradation. GSPT1 degrader-8 inhibits cell viability in HL-60 cells with an IC50 of 10 nM .
    GSPT1 degrader-10
  • HY-161749
    PROTAC ALK degrader-1

    		PROTACs Anaplastic lymphoma kinase (ALK) Cancer
    PROTAC ALK degrader-1 (compound B1) is an ALK degrader based on PROTACs, with the DC50 of 26 nM in H3122 EML4-ALK. PROTAC ALK degrader-1 can be used to synthesis PROTAC ALK degrader-2 (HY-161750) with superior bioavailability .
    PROTAC ALK degrader-1
  • HY-145737
    PROTAC SOS1 degrader-1

    		PROTACs Ras Cancer
    PROTAC SOS1 degrader-1 is a potent PROTAC SOS1 degrader with an DC50 of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity .
    PROTAC SOS1 degrader-1
  • HY-156591
    PROTAC MLKL Degrader-1

    		PROTACs Mixed Lineage Kinase Others
    PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC degrader of MLKL, with a Dmax ＞90%. PROTAC MLKL Degrader-1 contains modified CRBN ligands, linker and Lenalidomide (HY-A0003)-linker fragments. PROTAC MLKL Degrader-1 abrogates cell death in a TSZ model of necroptosis.
    PROTAC MLKL Degrader-1
  • HY-149963
    PROTAC CDK9 degrader-6

    		PROTACs CDK Cancer
    PROTAC CDK9 degrader-6 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-6 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-6 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively .
    PROTAC CDK9 degrader-6
  • HY-149962
    PROTAC CDK9 degrader-5

    		PROTACs CDK Cancer
    PROTAC CDK9 degrader-5 is a PROTAC targeting to CDK9 sepcifically. PROTAC CDK9 degrader-5 mediates CDK9 degradation via the proteasome. PROTAC CDK9 degrader-5 degrades CDK9 with DC50s of 0.10 μM and 0.14 μM for the CDK942 and CDK955 isoforms, respectively .
    PROTAC CDK9 degrader-5
  • HY-169271
    PROTAC SMARCA2 degrader-20

    		PROTACs Epigenetic Reader Domain Cancer
    PROTAC SMARCA2 degrader-20 (Compound I-40) is a PROTAC SMARCA2 degrader. PROTAC SMARCA2 degrader-20 has the potential for the research of cancer .
    PROTAC SMARCA2 degrader-20
  • HY-145073
    PROTAC ER Degrader-10

    		PROTACs Estrogen Receptor/ERR Cancer
    PROTAC ER Degrader-10 is a potent PROTAC ER degrader and can be used for cancer research. PROTAC ER Degrader-10 is extracted from patent WO2021133886, example 36.
    PROTAC ER Degrader-10
  • HY-155506
    NAMPT degrader-3

    		NAMPT Cancer
    NAMPT degrader-3 (compound C5) is a NAMPT degrader, depending on VHL- and proteasome manner. NAMPT degrader-3 displays cytotoxicity and inhibits A2780 cells proliferation .
    NAMPT degrader-3
  • HY-147654
    PROTAC Hemagglutinin Degrader-1

    		PROTACs Influenza Virus Infection
    PROTAC Hemagglutinin Degrader-1 (Compound V3) is a potent PROTAC influenza hemagglutinin (HA) degrader with a median degradation concentration of 1.44 μM. PROTAC Hemagglutinin Degrader-1 shows broad-spectrum anti-influenza virus activity .
    PROTAC Hemagglutinin Degrader-1
  • HY-129523
    PROTAC K-Ras Degrader-1
    2 Publications Verification

    		 PROTACs Ras Cancer
    PROTAC K-Ras Degrader-1 (Compound 518) is a PROTAC. PROTAC K-Ras Degrader-1 can effectively degrades K-Ras based on Cereblon E3 ligand, exhibits ≥70% degradation efficacy in SW1573 cells .
    PROTAC K-Ras Degrader-1
  • HY-169275
    PROTAC SMARCA2 degrader-24

    		PROTACs SWI/SNF Complex Cancer
    PROTAC SMARCA2 degrader-24 (Compound 34) is a PROTAC degrader for SMARCA2 with a DC50 < 0.1 µM in HeLa. PROTAC SMARCA2 degrader-24 degrades SMARCA4 with a DC50 > 10 μM in HeLa .
    PROTAC SMARCA2 degrader-24
  • HY-160531
    IKZF1-degrader-1

    		Molecular Glues IKZF Family Cancer
    IKZF1-degrader-1 (Compound 9-B) is a IKZF1 molecular glue degrader with the DC50 value of 0.134 nM. IKZF1-degrader-1 can be used to degrader tumors .
    IKZF1-degrader-1
  • HY-148691
    PROTAC PTPN2 degrader-1

    		Phosphatase PROTACs Metabolic Disease Cancer
    PROTAC PTPN2 degrader-1 (compound example 77) is a potent PTPN2 degrader. PROTAC PTPN2 degrader-1 has the potential for the research of cancer or metabolic disease .
    PROTAC PTPN2 degrader-1

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