2. PROTAC Epigenetics
  3. Molecular Glues Histone Acetyltransferase
  4. (R,R)-dWIZ-1 TFA

(R,R)-dWIZ-1 TFA is the the (R,R)-enantiomer of dWIZ-1 (HY-159098). dWIZ-1 is a potent WIZ molecular glue degrader. dWIZ-1 has the potential for the research of sickle cell disease (SCD).

For research use only. We do not sell to patients.

(R,R)-dWIZ-1 TFA

(R,R)-dWIZ-1 TFA Chemical Structure

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Based on 1 publication(s) in Google Scholar

Other Forms of (R,R)-dWIZ-1 TFA:

(R,R)-dWIZ-1 TFA Related Antibodies

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Description

(R,R)-dWIZ-1 TFA is the the (R,R)-enantiomer of dWIZ-1 (HY-159098). dWIZ-1 is a potent WIZ molecular glue degrader. dWIZ-1 has the potential for the research of sickle cell disease (SCD)[1].

Molecular Weight

513.51

Formula

C24H30F3N3O6
Appearance

Solid

Color

White to yellow

SMILES

O=C(O)C(F)(F)F.O=C(N1)C(CCC1=O)N(C2=O)CC3=C2C=CC(O[C@H](C)[C@@H]4N(CCCC4)CC)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (97.37 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9474 mL 9.7369 mL 19.4738 mL
5 mM 0.3895 mL 1.9474 mL 3.8948 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9474 mL 9.7369 mL 19.4738 mL 48.6845 mL
5 mM 0.3895 mL 1.9474 mL 3.8948 mL 9.7369 mL
10 mM 0.1947 mL 0.9737 mL 1.9474 mL 4.8685 mL
15 mM 0.1298 mL 0.6491 mL 1.2983 mL 3.2456 mL
20 mM 0.0974 mL 0.4868 mL 0.9737 mL 2.4342 mL
25 mM 0.0779 mL 0.3895 mL 0.7790 mL 1.9474 mL
30 mM 0.0649 mL 0.3246 mL 0.6491 mL 1.6228 mL
40 mM 0.0487 mL 0.2434 mL 0.4868 mL 1.2171 mL
50 mM 0.0389 mL 0.1947 mL 0.3895 mL 0.9737 mL
60 mM 0.0325 mL 0.1623 mL 0.3246 mL 0.8114 mL
80 mM 0.0243 mL 0.1217 mL 0.2434 mL 0.6086 mL
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(R,R)-dWIZ-1 TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R,R)-dWIZ-1Molecular GluesHistone AcetyltransferaseHATsHAT(R,R)-enantiomermolecular glue degraderSCDInhibitorinhibitorinhibit

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