2. PROTAC JAK/STAT Signaling Protein Tyrosine Kinase/RTK
  3. PROTACs EGFR FAK
  4. PROTAC EGFR degrader 11

PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 <100 nM. PROTAC EGFR degrader 11 binds CRBN-DDB1 with a Ki of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.

For research use only. We do not sell to patients.

PROTAC EGFR degrader 11

PROTAC EGFR degrader 11 Chemical Structure

CAS No. : 3034244-71-5

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Based on 1 publication(s) in Google Scholar

PROTAC EGFR degrader 11 Related Antibodies

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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Description

PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 <100 nM. PROTAC EGFR degrader 11 binds CRBN-DDB1 with a Ki of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.

IC50 & Target

CRBN-DDB1

36 nM (Ki)

Molecular Weight

991.61

Formula

C49H64ClFN10O7S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C2=C(F)C=C(N3CCC(OCCN(CC4)CCN4C(CC5)CCN5C(C(CC)=C6)=CC(OC)=C6NC7=NC=C(Cl)C(NC8=CC=C(OC)C=C8N(S(=O)(C)=O)C)=N7)CC3)C=C2)CCC(N1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (100.85 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0085 mL 5.0423 mL 10.0846 mL
5 mM 0.2017 mL 1.0085 mL 2.0169 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0085 mL 5.0423 mL 10.0846 mL 25.2115 mL
5 mM 0.2017 mL 1.0085 mL 2.0169 mL 5.0423 mL
10 mM 0.1008 mL 0.5042 mL 1.0085 mL 2.5212 mL
15 mM 0.0672 mL 0.3362 mL 0.6723 mL 1.6808 mL
20 mM 0.0504 mL 0.2521 mL 0.5042 mL 1.2606 mL
25 mM 0.0403 mL 0.2017 mL 0.4034 mL 1.0085 mL
30 mM 0.0336 mL 0.1681 mL 0.3362 mL 0.8404 mL
40 mM 0.0252 mL 0.1261 mL 0.2521 mL 0.6303 mL
50 mM 0.0202 mL 0.1008 mL 0.2017 mL 0.5042 mL
60 mM 0.0168 mL 0.0840 mL 0.1681 mL 0.4202 mL
80 mM 0.0126 mL 0.0630 mL 0.1261 mL 0.3151 mL
100 mM 0.0101 mL 0.0504 mL 0.1008 mL 0.2521 mL
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PROTAC EGFR degrader 11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC EGFR degrader 113034244-71-5PROTAC EGFR degrader11PROTAC EGFR degrader-11PROTACsEGFRFAKEpidermal growth factor receptorErbB-1HER1PTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseH1975HCC827BaF3Inhibitorinhibitorinhibit

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PROTAC EGFR degrader 11
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