2. Immunology/Inflammation Cell Cycle/DNA Damage Apoptosis
  3. NOD-like Receptor (NLR) NEKs Caspase Interleukin Related
  4. NLRP3 modulator 8

NLRP3 modulator 8 (Compound 14) is a NLRP3 modulator. NLRP3 modulator 8 significantly degrades NEK7 with an DC50 of 9  nM. NLRP3 modulator 8 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NLRP3 modulator 8 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research.

For research use only. We do not sell to patients.

NLRP3 modulator 8

NLRP3 modulator 8 Chemical Structure

CAS No. : 3069891-88-6

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NLRP3 modulator 8 Related Antibodies

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NLRP3 NLRP1 NOD1 NOD2

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NEK1 NEK2 NEK6 NEK7

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

NLRP3 modulator 8 (Compound 14) is a NLRP3 modulator. NLRP3 modulator 8 significantly degrades NEK7 with an DC50 of 9  nM. NLRP3 modulator 8 dose-dependently inhibits caspase-1 activity and IL-Ιβ release in macrophages in response to NLRP3 inflammasome activation. NLRP3 modulator 8 can be used for autoinflammatory and autoimmune disorders like multiple sclerosis, neurodegeneraive diseases like Alzheimer's disease and cardiovascular and melabolic disorders like pericarditis and Type 2 diabetes research[1].

IC50 & Target[1]

NEK7

9 nM (DC50)

Caspase-1

 

IL-1β

 

Molecular Weight

453.29

Formula

C20H19Cl2FN4O3
CAS No.
SMILES

O=C1NC(C(CC1)C2=C(C=C(CNC(C(C)(C)C3=NC=C(C=N3)F)=O)C=C2Cl)Cl)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NLRP3 modulator 8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NLRP3 modulator 83069891-88-6NOD-like Receptor (NLR)NEKsCaspaseInterleukin RelatedNIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed KinasesILNLRP3NEK7NLRP3 inflammasomeMultiple sclerosisAlzheimer's diseasePericarditisType 2 diabetesInhibitorinhibitorinhibit

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