3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde

Cat. No.: HY-W056267 Purity: ≥98.0%: Data Sheet
COA

SDS
Handling Instructions
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3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde is a PROTAC linker, and can be used for synthesis of PROTAC SOS1 degrader-8 (HY-161634).

For research use only. We do not sell to patients.

3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde Chemical Structure

CAS No. : 1416176-14-1

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50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Biological Activity
Purity & Documentation
References
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Description

3-Boc-3-azaspiro[5.5]undecane-9-carbaldehyde is a PROTAC linker, and can be used for synthesis of PROTAC SOS1 degrader-8 (HY-161634)^[1].

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

281.39

Formula

C₁₆H₂₇NO₃

CAS No.

1416176-14-1

Appearance

Solid-Liquid Mixture

Color

Colorless to off-white

SMILES

CC(C)(OC(N1CCC2(CC1)CCC(C=O)CC2)=O)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (355.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5538 mL	17.7689 mL	35.5379 mL
5 mM	0.7108 mL	3.5538 mL	7.1076 mL
10 mM	0.3554 mL	1.7769 mL	3.5538 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (246 KB) HNMR (242 KB) MS (72 KB)

Handling Instructions (2659 KB)

References

[1]. Ye Zhengqing, et al. Sos1 protein degradation agent and use thereof. Patent. WO2024083257A1

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5538 mL	17.7689 mL	35.5379 mL	88.8447 mL
	5 mM	0.7108 mL	3.5538 mL	7.1076 mL	17.7689 mL
	10 mM	0.3554 mL	1.7769 mL	3.5538 mL	8.8845 mL
	15 mM	0.2369 mL	1.1846 mL	2.3692 mL	5.9230 mL
	20 mM	0.1777 mL	0.8884 mL	1.7769 mL	4.4422 mL
	25 mM	0.1422 mL	0.7108 mL	1.4215 mL	3.5538 mL
	30 mM	0.1185 mL	0.5923 mL	1.1846 mL	2.9615 mL
	40 mM	0.0888 mL	0.4442 mL	0.8884 mL	2.2211 mL
	50 mM	0.0711 mL	0.3554 mL	0.7108 mL	1.7769 mL
	60 mM	0.0592 mL	0.2961 mL	0.5923 mL	1.4807 mL
	80 mM	0.0444 mL	0.2221 mL	0.4442 mL	1.1106 mL
	100 mM	0.0355 mL	0.1777 mL	0.3554 mL	0.8884 mL