2. PROTAC Immunology/Inflammation
  3. PROTACs BCL6 IKZF Family
  4. PROTAC BCL6/IKZF1/3 Degrader-1

PROTAC BCL6/IKZF1/3 Degrader-1 is a selective and orally active BCL6 and IKZF1/3 PROTAC degrader. PROTAC BCL6/IKZF1/3 Degrader-1 exhibits superior antiproliferative effects in various germinal center B-cell-like (GCB) and activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) cell lines. PROTAC BCL6/IKZF1/3 Degrader-1 can be used for the research of cancer, such as lymphoma. (Structure Note: Pink: BCL6/IKZF1/3 ligand (HY-179064); Blue: CRBN ligand (HY-41547); Black: linker (HY-42427); CRBN ligand-Linker: (HY-179066))

For research use only. We do not sell to patients.

PROTAC BCL6/IKZF1/3 Degrader-1

PROTAC BCL6/IKZF1/3 Degrader-1 Chemical Structure

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PROTAC BCL6/IKZF1/3 Degrader-1 Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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IKZF1 IKZF2 IKZF3 IKZF4

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Description

PROTAC BCL6/IKZF1/3 Degrader-1 is a selective and orally active BCL6 and IKZF1/3 PROTAC degrader. PROTAC BCL6/IKZF1/3 Degrader-1 exhibits superior antiproliferative effects in various germinal center B-cell-like (GCB) and activated B-cell-like (ABC) diffuse large B-cell lymphoma (DLBCL) cell lines. PROTAC BCL6/IKZF1/3 Degrader-1 can be used for the research of cancer, such as lymphoma[1]. (Structure Note: Pink: BCL6/IKZF1/3 ligand (HY-179064); Blue: CRBN ligand (HY-41547); Black: linker (HY-42427); CRBN ligand-Linker: (HY-179066))

IC50 & Target[1]

IKZF1

 

IKZF3

 

Cereblon

 

In Vitro

PROTAC BCL6/IKZF1/3 Degrader-1 (Compound BC6) (0.03-100 nM, 24 h) specifically degrades BCL6, IKZF1, and IKZF3 proteins (BCL6: DC50 = 0.08-1.04 nM, IKZF1: DC50 = 5.74-26.32 nM, IKZF3: DC50 = 1.05-6.40 nM) in GCB/ABC subtype diffuse large B-cell lymphoma (DLBCL) cells including OCI-ly1, OCI-ly10, and SU-DHL4 cells[1].
PROTAC BCL6/IKZF1/3 Degrader-1 (0.03-100 nM, 24 h) significantly inhibits OCI-ly1, OCI-ly10, and SU-DHL4 cells proliferation (IC50 = 0.46-35.68 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC BCL6/IKZF1/3 Degrader-1 Related Antibodies
In Vivo

PROTAC BCL6/IKZF1/3 Degrader-1 (Compound BC6) (25-50 mg/kg, p.o., daily for 21 days) significantly inhibits tumor growth with tumor growth in NOD-SCID mice bearing OCI-ly1 xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week-old female NOD-SCID mice bearing OCI-ly1 xenografts[1]
Dosage: 25 and 50 mg/kg
Administration: Orally administration, daily for 21 days
Result: Showed tumor growth inhibition (TGI) rates of 63.55% and 72.23%.
Reduced tumor weight.
Degraded BCL6 and IKZF1/3 proteins in tumor tissues.
Showed no significant body weight changes.
Molecular Weight

853.36

Formula

C43H49ClN10O7
SMILES

CNC(COC1=CC2=C(N(C1=O)C)C=CC(NC3=NC(N4CCC(CC4)CN5CCC(CC5)CCNC6=CC=CC7=C6C(N(C7=O)C8CCC(NC8=O)=O)=O)=NC=C3Cl)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC BCL6/IKZF1/3 Degrader-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BCL6/IKZF1/3 Degrader-1PROTACsBCL6IKZF FamilyB-cell lymphoma 6 proteinB-cell lymphoma 5 protein (BCL-5)Zinc finger and BTB domain-containing protein 27Zinc finger protein 51Ikaros zinc finger protein familyIKZF1IKZF3antiproliferativeDLBCLlymphomaOCI-ly1OCI-ly10SU-DHL4Inhibitorinhibitorinhibit

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