2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. PROTAC BRD4 Degrader-40

PROTAC BRD4 Degrader-40 is a Bromodomain protein 4 (BRD4) PROTAC degrader. PROTAC BRD4 Degrader-40 can induce BRD4 degradation in cancer cells. PROTAC BRD4 Degrader-40 can be used for the research of cancer, such as leukemia. (Structure Note: Pink: BRD4 ligand (HY-78695); Blue: CRBN ligand (HY-163927))

For research use only. We do not sell to patients.

PROTAC BRD4 Degrader-40

PROTAC BRD4 Degrader-40 Chemical Structure

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PROTAC BRD4 Degrader-40 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC BRD4 Degrader-40 is a Bromodomain protein 4 (BRD4) PROTAC degrader. PROTAC BRD4 Degrader-40 can induce BRD4 degradation in cancer cells. PROTAC BRD4 Degrader-40 can be used for the research of cancer, such as leukemia[1]. (Structure Note: Pink: BRD4 ligand (HY-78695); Blue: CRBN ligand (HY-163927))

IC50 & Target[1]

BRD4

 

Cereblon

 

In Vitro

PROTAC BRD4 Degrader-40 (Compound 5Y-3) (0.1-1 μM, 24 h) induces BRD4 degradation in SUDHL-4 and MV-4-11 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PROTAC BRD4 Degrader-40 Related Antibodies

Western Blot Analysis[1]

Cell Line: SUDHL-4 and MV-4-11 cells
Concentration: 0.1 and 1 μM
Incubation Time: 24 h
Result: Reduced BRD4 levels.
Molecular Weight

760.26

Formula

C39H34ClN9O4S
SMILES

O=C(N/N=C\C1=CC=C(C2=C(N3C)C(N(C(CC4)C(NC4=O)=O)C3=O)=CC=C2)C=C1)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC BRD4 Degrader-40 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BRD4 Degrader-40PROTACsEpigenetic Reader DomainBRD4cancerSUDHL-4MV-4-11leukemiaInhibitorinhibitorinhibit

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