2. Metabolic Enzyme/Protease
  3. Drug Metabolite
  4. all-trans-Anhydro Retinol

all-trans-Anhydro Retinol  (Synonyms: Anhydrovitamin A)

Cat. No.: HY-N7495 Purity: 90.95%
SDS
COA
Handling Instructions Technical Support

all-trans-Anhydro Retinol (Anhydrovitamin A) is an orally active degradation product formed by the dehydration of vitamin A alcohol and its esters under conditions such as acidic catalysis or hydroxylic solvents, with a biological activity only 0.4% of that of Vitamin A (HY-B1342). In rats, all-trans-Anhydro Retinol can be metabolized into hydroxy derivatives and their esters, but it cannot be converted into Vitamin A (HY-B1342) and has a low storage capacity in the body.

For research use only. We do not sell to patients.

all-trans-Anhydro Retinol Chemical Structure

all-trans-Anhydro Retinol Chemical Structure

CAS No. : 1224-78-8

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Other Forms of all-trans-Anhydro Retinol:

all-trans-Anhydro Retinol Related Antibodies

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Description

all-trans-Anhydro Retinol (Anhydrovitamin A) is an orally active degradation product formed by the dehydration of vitamin A alcohol and its esters under conditions such as acidic catalysis or hydroxylic solvents, with a biological activity only 0.4% of that of Vitamin A (HY-B1342). In rats, all-trans-Anhydro Retinol can be metabolized into hydroxy derivatives and their esters, but it cannot be converted into Vitamin A (HY-B1342) and has a low storage capacity in the body[1][2].

In Vivo

all-trans-Anhydro Retinol (2.22 mg; oral administration/subcutaneous injection; 6 days) in Vitamin A (HY-B1342)-deficient rats shows that it is metabolized into various monohydroxy, dihydroxy and ester derivatives through hydroxylation and esterification, with no detectable Vitamin A (HY-B1342) or unmetabolized Anhydrovitamin A in the liver[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (approximately 7 weeks old) made Vitamin A (HY-B1342)-deficient by dietary restriction[1]
Dosage: 0.22 mg/0.1 mL
Administration: Oral administration/subcutaneous injection; 6 days
Result: Was metabolized into at least seven derivatives in the liver, including non-hydroxy, monohydroxy, and dihydroxy compounds with ester groups. The metabolites were poorly absorbed and stored, with no detectable levels remaining in the liver after 30 days.
Resulted in 26% of the liver storage by subcutaneous injection compared to oral administration. The growth-promoting activity was attributed to the in vivo-formed derivatives rather than conversion to vitamin A.
Molecular Weight

268.44

Formula

C20H28
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1(C)CCC=C(C)/C1=C/C=C(C)/C=C/C=C(C)/C=C
Structure Classification
Initial Source
Shipping

Shipping with dry ice.
Storage

-80°C, protect from light, stored under nitrogen
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (37.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7252 mL 18.6261 mL 37.2523 mL
5 mM 0.7450 mL 3.7252 mL 7.4505 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 93.06%

SDS (251 KB)

COA (243 KB) HNMR (262 KB) LCMS (85 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7252 mL 18.6261 mL 37.2523 mL 93.1307 mL
5 mM 0.7450 mL 3.7252 mL 7.4505 mL 18.6261 mL
10 mM 0.3725 mL 1.8626 mL 3.7252 mL 9.3131 mL
15 mM 0.2483 mL 1.2417 mL 2.4835 mL 6.2087 mL
20 mM 0.1863 mL 0.9313 mL 1.8626 mL 4.6565 mL
25 mM 0.1490 mL 0.7450 mL 1.4901 mL 3.7252 mL
30 mM 0.1242 mL 0.6209 mL 1.2417 mL 3.1044 mL
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all-trans-Anhydro Retinol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

all-trans-Anhydro Retinol1224-78-8Anhydrovitamin ADrug MetaboliteVitamin AMetaboliteInhibitorinhibitorinhibit

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