2. NF-κB Stem Cell/Wnt JAK/STAT Signaling
  3. NF-κB STAT
  4. Thienodolin

Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 murine macrophage cells with an IC50 value of 17.2 μM. Thienodolin suppresses iNOS, blocks the degradation of IκBα, attenuates NF-κB p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation.

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Thienodolin

Thienodolin Chemical Structure

CAS No. : 149127-27-5

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Thienodolin Related Antibodies

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Description

Thienodolin (MJ 286A) is an alkaloid that has been found in S. albogriseolus. Thienodolin inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 murine macrophage cells with an IC50 value of 17.2 μM. Thienodolin suppresses iNOS, blocks the degradation of IκBα, attenuates NF-κB p65 accumulation in the nucleus, and reduces the phosphorylation level of STAT1 at Tyr701. Thienodolin can be used for the study of inflammation[1].

In Vitro

Thienodolin (6.25-50 μM, 15 min pretreatment) inhibits nitric oxide production in LPS (HY-D1056)-stimulated RAW 264.7 cells (IC50 = 17.2 μM)[1].
Thienodolin (6.25-50 μM, 5-18 h) suppresses iNOS expression in a dose-dependent manner at both mRNA and protein levels in LPS-stimulated RAW 264.7 cells[1].
Thienodolin (6.25-50 μM, 15 min pretreatment) blocks the degradation of IκBα, reduces the phosphorylation level of STAT1 at Tyr701 and attenuates NF-κB p65 accumulation in the nucleus in LPS-stimulated RAW 264.7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thienodolin Related Antibodies

Western Blot Analysis[1]

Cell Line: LPS-stimulated RAW 264.7 cells
Concentration: 6.25, 12.5, 25, 50 μM
Incubation Time: 15 min pretreatment
Result: Blocked the degradation of IκBα.
Reduced the phosphorylation level of STAT1 at Tyr701.
Attenuated NF-κB p65 accumulation in the nucleus.
Molecular Weight

250.70

Formula

C11H7ClN2OS
CAS No.
SMILES

O=C(C1=CC2=C(NC3=C2C=CC(Cl)=C3)S1)N
Structure Classification
Initial Source

Streptomyces albogriseolus
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Thienodolin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thienodolin149127-27-5MJ 286ANF-κBSTATNuclear factor-κBNuclear factor-kappaBS. albogriseolusNF-κB p65inflammationInhibitorinhibitorinhibit

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