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  3. Drug Intermediate
  4. pCR8

pCR8 is a prodrug of CR8 (HY-18340). pCR8 is amphiphilic and can self-assemble into nanoparticles. pCR8 can release CR8 under the action of high concentration of H2O2 in the tumor microenvironment. CR8 is a molecular glue degrader that can effectively degrade cell cycle-related proteins and has antitumor activity. pCR8 can be used in the research of tumors such as breast cancer.

For research use only. We do not sell to patients.

pCR8 Chemical Structure

pCR8 Chemical Structure

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pCR8 Related Antibodies

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Description

pCR8 is a prodrug of CR8 (HY-18340). pCR8 is amphiphilic and can self-assemble into nanoparticles. pCR8 can release CR8 under the action of high concentration of H2O2 in the tumor microenvironment. CR8 is a molecular glue degrader that can effectively degrade cell cycle-related proteins and has antitumor activity. pCR8 can be used in the research of tumors such as breast cancer[1].

Molecular Weight

609.48

Formula

C32H36BN7O5
SMILES

CC[C@@H](COC(OCC1=CC=C(B(O)O)C=C1)=O)NC2=NC(NCC(C=C3)=CC=C3C4=CC=CC=N4)=C(N=CN5C(C)C)C5=N2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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pCR8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

pCR8pCR 8pCR-8Drug IntermediateDrug Iintermediateprodrugnanoparticlestumor microenvironmentbreast cancerNIH3T34T1Inhibitorinhibitorinhibit

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