2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Protoporphyrin IX disodium

Protoporphyrin IX disodium is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX disodium also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX disodium is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX disodium causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX disodium is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma.

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Protoporphyrin IX disodium Chemical Structure

Protoporphyrin IX disodium Chemical Structure

CAS No. : 50865-01-5

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Based on 20 publication(s) in Google Scholar

Other Forms of Protoporphyrin IX disodium:

Protoporphyrin IX disodium Related Antibodies

Top Publications Citing Use of Products

    Protoporphyrin IX disodium purchased from MedChemExpress. Usage Cited in: Genome Biol. 2022 Dec 15;23(1):259.  [Abstract]

    Protoporphyrin IX (PpIX; 0, 5, 15, 25 µM; 2 h) rapidly results in increased nuclear G4 levels in HeLa cells. Immunostaining of G4 using BG4-EGFP (green). The nuclei are stained with DAPI (blue).

    Protoporphyrin IX disodium purchased from MedChemExpress. Usage Cited in: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015 Jul;27(7):568-73.  [Abstract]

    To determine whether the inhibition of caveolin-1 tyrosine residues 14 ( Cav-1-Y14 ) phosphorylation with protein tyrosine kinase inhibitors ( PP2 ) will upregulate heme oxygenase-1 ( HO-1 ) activity to protect against ventilation induced lung injury in vivo of an animal model. The group D1 or D2 receive high tidal volume ventilation for 1 hour or 2 hour respectively, but they are given PP2 1 hour before high tidal volume ventilation. The groups E1 and E2 also receive high tidal volume ventilat

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    Description

    Protoporphyrin IX disodium is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX disodium also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX disodium is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX disodium causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX disodium is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma[1][2][3][4][5].

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Protoporphyrin IX disodium (3.6 nmol/g tissue) tissue can cause necrosis in normal rat colonic mucosa on exposure to light[4].
    Protoporphyrin IX disodium (6.6 nmol/g tumor) delays tumor growth after irradiation of a tumor in rats[4].
    Protoporphyrin IX disodium (0-25 μM, 2 h) rapidly results in increased nuclear G4 levels in Hela cells[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Protoporphyrin IX disodium Related Antibodies
    In Vivo

    The highest level of Protoporphyrin IX disodium (approximately 6.3 nmol/g tissue) is found in rat liver and intestine, followed by aorta (4.3 nmol/g tissue) and oesophagus (2.1 nmol/g tissue), 3 h after Aminolevulinic acid (300 mg/kg, i.v., a single dose) administration[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    606.62

    Formula

    C34H32N4Na2O4
    CAS No.
    Appearance

    Solid

    Color

    Brown to black

    SMILES

    O=C(O[Na])CCC1=C2/C=C3C(CCC(O[Na])=O)=C(C)C(/C=C(N/4)/C(C)=C(C=C)C4=C\C5=N/C(C(C=C)=C5C)=C\C(N2)=C1C)=N/3
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 5 mg/mL (8.24 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.6485 mL 8.2424 mL 16.4848 mL
    5 mM 0.3297 mL 1.6485 mL 3.2970 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Purity & Documentation

    Purity: 96.5%

    SDS (393 KB)

    COA (261 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.6485 mL 8.2424 mL 16.4848 mL 41.2120 mL
    5 mM 0.3297 mL 1.6485 mL 3.2970 mL 8.2424 mL
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    Protoporphyrin IX disodium Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Protoporphyrin IX disodium50865-01-5Endogenous Metaboliteintermediateheme biosynthetictumor cellsratsenterohepatic circulationbasal cell carcinomasonodynamicphotodynamicbladder cancerInhibitorinhibitorinhibit

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