2. PROTAC Cell Cycle/DNA Damage
  3. Molecular Glues NEKs
  4. MRT-3486

MRT-3486 (Compound 5) is a cereblon-based NEK7 molecular glue degrader. MRT-3486 can be used for autoinflammatory diseases research.

For research use only. We do not sell to patients.

MRT-3486

MRT-3486 Chemical Structure

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MRT-3486 Related Antibodies

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NEK1 NEK2 NEK6 NEK7

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Description

MRT-3486 (Compound 5) is a cereblon-based NEK7 molecular glue degrader. MRT-3486 can be used for autoinflammatory diseases research[1].

IC50 & Target[1]

NEK7

 

Molecular Weight

571.65

Formula

C30H29N5O5S
SMILES

O=C([C@H]1N(S(=O)(CC2=CC=CC=C2)=O)CCC3=C1C=CC=C3)NCC4=CC5=NC(C(CC6)C(NC6=O)=O)=CN5C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MRT-3486 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MRT-3486MRT3486MRT 3486Molecular GluesNEKsNIMA–related KinasesNIMA (never in mitosis gene a)-related Expressed KinasesMolecular glue degraderCereblonNEK7CAL51 cellsHEK293T cellsAutoinflammatory diseasesInhibitorinhibitorinhibit

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HY-175452
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