2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. TLT8

TLT8 is a ByeTAC protein degrader targeting BTK. TLT8 non-covalently binds to Rpn-13 and BTK, thereby inducing BTK degradation. TLT8 can be used in chronic lymphocytic leukemia research. (Rpn-13 ligand: HY-159808; BTK ligand: HY-Z3101; linker: HY-172823).

For research use only. We do not sell to patients.

TLT8 Chemical Structure

TLT8 Chemical Structure

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TLT8 Related Antibodies

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Description

TLT8 is a ByeTAC protein degrader targeting BTK. TLT8 non-covalently binds to Rpn-13 and BTK, thereby inducing BTK degradation. TLT8 can be used in chronic lymphocytic leukemia research. (Rpn-13 ligand: HY-159808; BTK ligand: HY-Z3101; linker: HY-172823)[1].

Molecular Weight

1340.77

Formula

C63H76BrClN12O12S
SMILES

NC1=C2C(C3=CC=C(C=C3)OC4=CC=CC=C4)=NN(C2=NC=N1)[C@H]5CCCN(C5)C(CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CC6SC7=NN=C(N7N=C6C8=CC=C(C=C8)Cl)CC9=CC=C(C=C9)Br)=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TLT8 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLT8TLT 8TLT-8BtkBruton tyrosine kinaseByeTACchronic lymphocytic leukemiahematologicalInhibitorinhibitorinhibit

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