JQ1-S(GlcNAc)Cq

Cat. No.: HY-178510: Data Sheet Handling Instructions
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JQ1-S(GlcNAc)Cq is a sugar-coated BRD4 PROTAC degrader. JQ1-S(GlcNAc)Cq can inhibit the formation of the ternary complex between CRBN and BRD4(BD1/BD2). JQ1-S(GlcNAc)Cq can be used for the research of cancer. (Structure Note: Pink: BRD4 ligand (HY-78695); Blue: CRBN ligand (HY-178514); Black: linker (HY-W105727); BRD4 ligand-Linker: (HY-178519))

For research use only. We do not sell to patients.

JQ1-S(GlcNAc)Cq Chemical Structure

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Biological Activity
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References
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Description

JQ1-S(GlcNAc)Cq is a sugar-coated BRD4 PROTAC degrader. JQ1-S(GlcNAc)Cq can inhibit the formation of the ternary complex between CRBN and BRD4(BD1/BD2). JQ1-S(GlcNAc)Cq can be used for the research of cancer^[1]. (Structure Note: Pink: BRD4 ligand (HY-78695); Blue: CRBN ligand (HY-178514); Black: linker (HY-W105727); BRD4 ligand-Linker: (HY-178519))

IC₅₀ & Target^[1]

Cereblon

BRD4(BD1BD2)

In Vitro

JQ1-S(GlcNAc)cQ significantly inhibits the formation of the ternary complex between CRBN and BRD4(BD1/BD2)^[1].
JQ1-S(GlcNAc)cQ induce BRD4 degradation in HEK293T cells with a DC₅₀ of 2.1 μM^[1].
JQ1-S(GlcNAc)cQ inhibits cell growth in HEK293T cells with a GI₅₀ >316 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	HEK293T cells
Concentration:	0.1, 0.4, 1.1, 3.3 and 10 μM
Incubation Time:	12 h
Result:	Reduced α-BRD4 expression.

Molecular Weight

956.50

Formula

C₄₄H₅₈ClN₉O₁₁S

SMILES

O=C(N1)[C@@H](NC([C@H](CO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2NC(C)=O)NC(CCCCCCCCNC(C[C@@H]3N=C(C4=CC=C(Cl)C=C4)C5=C(SC(C)=C5C)N6C3=NN=C6C)=O)=O)=O)CCC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhu Q, et al. Enzyme-Activated Sugar-Coated Bifunctional Degraders. J Am Chem Soc. 2025 Sep 24;147(38):34672-34680.

JQ1-S(GlcNAc)Cq Related Classifications

Cancer

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JQ1-S(GlcNAc)CqPROTACsEpigenetic Reader DomainHEK293TBRD4PROTACBD1BD2cancerCRBNInhibitorinhibitorinhibit

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