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  3. Molecular Glues
  4. GSPT1 degrader-11

GSPT1 degrader-11 is a CRBN-dependent G1 to S phase transition 1 (GSPT1) molecular glue degrader (DC50 = 67.7 nM, Dmax = 97%). GSPT1 degrader-11 can inhibit MDA-MB-231 CRBN-WT cells proliferation (IC50 = 2.07 μM). GSPT1 degrader-11 can be used for the research of cancer.

For research use only. We do not sell to patients.

GSPT1 degrader-11

GSPT1 degrader-11 Chemical Structure

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GSPT1 degrader-11 Related Antibodies

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Description

GSPT1 degrader-11 is a CRBN-dependent G1 to S phase transition 1 (GSPT1) molecular glue degrader (DC50 = 67.7 nM, Dmax = 97%). GSPT1 degrader-11 can inhibit MDA-MB-231 CRBN-WT cells proliferation (IC50 = 2.07 μM). GSPT1 degrader-11 can be used for the research of cancer[1].

Molecular Weight

771.87

Formula

C41H45N11O5
SMILES

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC(N4CC(N5CCC(C(N6CCN(C7=CC=C(NC8=NC=C9N=C(C%10CC%10)N(C)C9=N8)C=C7)CC6)=O)CC5)C4)=C3)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSPT1 degrader-11 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSPT1 degrader-11Molecular GluesCRBNmolecular glueMDA-MB-231 CRBN-WTcancerInhibitorinhibitorinhibit

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