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CORM-A1  (Synonyms: Sodium boranocarbonate)

Cat. No.: HY-W782399 Purity: ≥95.0%
COA
SDS
Handling Instructions Technical Support

CORM-A1 (Sodium boranocarbonate) is a water-soluble carbon monoxide (CO) releasing molecule that facilitates the investigation of CO's impact on cellular systems. As CO is generated from heme degradation by the enzyme heme oxygenase, it serves as a crucial gaseous signaling mediator in mammalian cells. CORM-A1 not only exhibits anti-oxidant and anti-inflammatory properties but also regulates CO release in a manner dependent on pH and temperature, promoting mild vasorelaxation and hypotension. Furthermore, CORM-A1 has been shown to provide cytoprotection in primary cultures of astrocytes under oxidative stress while also enhancing autophagy due to its boron-containing composition.

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CORM-A1 Chemical Structure

CORM-A1 Chemical Structure

CAS No. : 17363-08-5

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10 mg In-stock
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100 mg   Get quote  

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Description

CORM-A1 (Sodium boranocarbonate) is a water-soluble carbon monoxide (CO) releasing molecule that facilitates the investigation of CO's impact on cellular systems. As CO is generated from heme degradation by the enzyme heme oxygenase, it serves as a crucial gaseous signaling mediator in mammalian cells. CORM-A1 not only exhibits anti-oxidant and anti-inflammatory properties but also regulates CO release in a manner dependent on pH and temperature, promoting mild vasorelaxation and hypotension. Furthermore, CORM-A1 has been shown to provide cytoprotection in primary cultures of astrocytes under oxidative stress while also enhancing autophagy due to its boron-containing composition.

Molecular Weight

103.82

Formula

CH3BNa2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Na][Na].O=C=O.B
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (481.60 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.6321 mL 48.1603 mL 96.3206 mL
5 mM 1.9264 mL 9.6321 mL 19.2641 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥95.0%

SDS (393 KB)

COA (246 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 9.6321 mL 48.1603 mL 96.3206 mL 240.8014 mL
5 mM 1.9264 mL 9.6321 mL 19.2641 mL 48.1603 mL
10 mM 0.9632 mL 4.8160 mL 9.6321 mL 24.0801 mL
15 mM 0.6421 mL 3.2107 mL 6.4214 mL 16.0534 mL
20 mM 0.4816 mL 2.4080 mL 4.8160 mL 12.0401 mL
25 mM 0.3853 mL 1.9264 mL 3.8528 mL 9.6321 mL
30 mM 0.3211 mL 1.6053 mL 3.2107 mL 8.0267 mL
40 mM 0.2408 mL 1.2040 mL 2.4080 mL 6.0200 mL
50 mM 0.1926 mL 0.9632 mL 1.9264 mL 4.8160 mL
60 mM 0.1605 mL 0.8027 mL 1.6053 mL 4.0134 mL
80 mM 0.1204 mL 0.6020 mL 1.2040 mL 3.0100 mL
100 mM 0.0963 mL 0.4816 mL 0.9632 mL 2.4080 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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CORM-A1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CORM-A117363-08-5Sodium boranocarbonateOthersInhibitorinhibitorinhibit

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