Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 

Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 (Compound 3) is a "linker-payload" component of an antibody-drug conjugate (ADC). Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 selectively delivers the dual-function BTK degrader to B-cell malignancies by targeting the monoclonal antibody of CD79b. Mal-PEG1-Val-Cit-PABC-diphosphate-BTK degrader-1 can be coupled to the engineered CD79b antibody with cysteine, forming CD79b-3 ADC (ADC linker: (HY-130944); Protac: (HY-163295)).

1671.63

C₈₀H₉₄F₂N₁₄O₂₀P₂

COC1=C(N2CCC(N(COP(O)(OP(O)(OCC3=CC=C(NC([C@H](CCCNC(N)=O)NC([C@@H](NC(CCOCCN4C(C=CC4=O)=O)=O)C(C)C)=O)=O)C=C3)=O)=O)C2=O)=O)C=C(C(N5CCC6(CCN(CCC7=CC=C(C8=CC9=C(N=CN=C9C%10=CC(F)=CC(NC(C%11=CC=C(C(O)(C)C)C=C%11F)=O)=C%10C)N8)C=C7)CC6)CC5)=O)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang A, et al. Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton's Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody-Drug Conjugates. Bioconjug Chem. 2024;35(2):140-146.  [Content Brief]