2. Metabolic Enzyme/Protease Apoptosis
  3. Cathepsin Apoptosis
  4. NCO-700

NCO-700 is a dual cathepsin B and calcium-activated neutral protease (CANP) inhibitor with IC50 values of 0.8 and 46 μM, respectively. NCO-700 reduces the degradation of myocardial fibrin by inhibiting protease activity. NCO-700 also has inhibitory effects on hormone-independent tumor cells, such as prostate cancer cells, and induces apoptosis. NCO-700 can be used to study myocardial ischemia and refractory hormone-independent tumors.

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NCO-700

NCO-700 Chemical Structure

CAS No. : 84518-80-9

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NCO-700 Related Antibodies

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Description

NCO-700 is a dual cathepsin B and calcium-activated neutral protease (CANP) inhibitor with IC50 values of 0.8 and 46 μM, respectively. NCO-700 reduces the degradation of myocardial fibrin by inhibiting protease activity. NCO-700 also has inhibitory effects on hormone-independent tumor cells, such as prostate cancer cells, and induces apoptosis. NCO-700 can be used to study myocardial ischemia and refractory hormone-independent tumors[1][2].

In Vitro

NCO-700 (7 days) inhibits HS-578T, PC-3, DU-145, MCF-7, LNCaP and T47D cells proliferation with IC50s of 7.5, 10, 11.5, 72 and >100 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NCO-700 Related Antibodies
In Vivo

NCO-700 (total dose: 20-40 mg/kg, i.p., 4 administrations of medication) reduces the infarct area in the rabbit and doy myocardial infarction model[1][3].
NCO-700 (10-100 mg/kg, i.p., once daily for 5 days) demonstrates significant anti-tumor activity in xenograft models of prostate cancer and breast cancer in mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Myocardial infarction model established in male albino rabbit and mongrel dog[1][3]
Dosage: 20 and 40 mg/kg (total dose)
Administration: Intraperitoneal injection (i.p.), 4 administrations of medication
Result: Reduce the infarcted area by 11.5% and 22.3% at 20 and 40 mg/kg in rabbit model.
Significantly inhibited the degradation of myofibrillar proteins induced by ischemia in dog model.
Animal Model: Xenograft models of prostate cancer and breast cancer established in Balb/C mice[2]
Dosage: 10, 20 and 40 mg/kg (prostate cancer) and 10, 50 and 100 mg/kg (breast cancer)
Administration: Intraperitoneal injection (i.p.), once daily for 5 days
Result: Significantly slowed down the growth rate of the tumor.
Induced cell apoptosis in cancer cells removed from animals.
Molecular Weight

521.60

Formula

C26H39N3O8
CAS No.
SMILES

O=C(N1CCN(CC2=C(C(OC)=C(OC)C=C2)OC)CC1)[C@H](CC(C)C)NC([C@H]3[C@H](C(OCC)=O)O3)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NCO-700 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NCO-70084518-80-9NCO700NCO 700CathepsinApoptosisCalcium-activatedneutral proteaseProtease inhibitorAcute myocardial infarctionContractilityInhibitorinhibitorinhibit

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