2. PROTAC Immunology/Inflammation
  3. BCL6 PROTACs
  4. ARV-393

ARV-393 is a potent and orally active BCL6 PROTAC degrader. ARV-393 induces ubiquitination of BCL6 and its subsequent degradation by the proteasome. ARV-393 has the potential for the research of advanced non-hodgkin lymphoma.

For research use only. We do not sell to patients.

ARV-393 Chemical Structure

ARV-393 Chemical Structure

CAS No. : 2851885-95-3

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Based on 1 publication(s) in Google Scholar

ARV-393 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

ARV-393 is a potent and orally active BCL6 PROTAC degrader. ARV-393 induces ubiquitination of BCL6 and its subsequent degradation by the proteasome. ARV-393 has the potential for the research of advanced non-hodgkin lymphoma[1][2][3].

IC50 & Target

BCL6[1]
In Vitro

ARV-393 has DC50 and GI50 values of <1 nM in multiple cell lines of diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ARV-393 Related Antibodies
In Vivo

ARV-393 (3, 10, 30 mg/kg; po; once daily for 23 days) shows anticancer activity in xenograft model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (OCI-Ly1 cell line xenograft model)[3]
Dosage: 3, 10, 30 mg/kg
Administration: PO; once daily for 23 days (3 mg/kg; twice daily for 23 days)
Result: Ihibited tumor growth and induced BCL6 protein degradation.
Molecular Weight

898.42

Formula

C46H53ClFN9O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

ClC1=CN=C(N2CCC(O[C@@H]3C[C@@H](N4CCC(C5=C(F)C(CN(C6CCC(NC6=O)=O)C7=O)=C7C=C5)CC4)C3)CC2)N=C1NC8=CC(C=C(OCC(NC)=O)C(N9C(C)C)=O)=C9C=C8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (22.26 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1131 mL 5.5653 mL 11.1307 mL
5 mM 0.2226 mL 1.1131 mL 2.2261 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.43%

SDS (252 KB)

COA (252 KB) HNMR (349 KB) RP-HPLC (248 KB) MS (69 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1131 mL 5.5653 mL 11.1307 mL 27.8266 mL
5 mM 0.2226 mL 1.1131 mL 2.2261 mL 5.5653 mL
10 mM 0.1113 mL 0.5565 mL 1.1131 mL 2.7827 mL
15 mM 0.0742 mL 0.3710 mL 0.7420 mL 1.8551 mL
20 mM 0.0557 mL 0.2783 mL 0.5565 mL 1.3913 mL
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ARV-393 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARV-3932851885-95-3ARV393ARV 393BCL6PROTACsB-cell lymphoma 6 proteinB-cell lymphoma 5 protein (BCL-5)Zinc finger and BTB domain-containing protein 27Zinc finger protein 51Orally activeubiquitin-proteasome systemE3 ligasediffuse large B-cell lymphomaDLBCLBurkitt lymphomanon-Hodgkin lymphomaInhibitorinhibitorinhibit

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