2-5A pentasodium  (Synonyms: 5'-O-Triphosphoryladenylyl-(2'→5')-adenylyl-(2'→5')-adenosine pentasodium)

2-5A (5'-O-Triphosphoryladenylyl-(2'→5')-adenylyl-(2'→5')-adenosine) pentasodium is a 5'-triphosphorylated (2',5') oligoadenylate. 2-5A pentasodium is an immunotransmitter that fuels RNase L immunity. 2-5A pentasodium degrades viral mRNA and inhibits protein synthesis by binding to RNase L and activating its endoribonuclease activity. 2-5A pentasodium can be used in RSV and cancer research^[1][2][3][4].

1275.50

C₃₀H₃₅N₁₅Na₅O₂₅P₅

NC1=NC=NC2=C1N=CN2[C@H]3[C@H](OP(OC[C@@H](O[C@H]([C@@H]4OP(OC[C@@H](O[C@H]([C@@H]5O)N6C=NC7=C6N=CN=C7N)[C@H]5O)(O[Na])=O)N8C=NC9=C8N=CN=C9N)[C@H]4O)(O[Na])=O)[C@H](O)[C@@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)O3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kalinichenko EN, et al. 3'-Fluoro-3'-deoxy analogs of 2-5A 5'-monophosphate: binding to 2-5A-dependent endoribonuclease and susceptibility to (2'-5')phosphodiesterase degradation. Biochem Biophys Res Commun. 1990 Feb 28;167(1):20-6.  [Content Brief]

  [2]. Barnard DL, et al. 2-5A-DNA conjugate inhibition of respiratory syncytial virus replication: effects of oligonucleotide structure modifications and RNA target site selection. Antiviral Res. 1999 Apr;41(3):119-34.  [Content Brief]

  [3]. Wang S, Li L. 2-5A is an immunotransmitter that fuels RNase L immunity. Immunity. 2025 Apr 8;58(4):770-772.  [Content Brief]

  [4]. Huai W, et al. OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity. Immunity. 2025 Apr 8;58(4):797-810.e6. doi: 10.1016/j.immuni.2025.01.016. Epub 2025 Feb 25.  [Content Brief]