2. Academic Validation
  3. 2-5A is an immunotransmitter that fuels RNase L immunity

2-5A is an immunotransmitter that fuels RNase L immunity

  • Immunity. 2025 Apr 8;58(4):770-772. doi: 10.1016/j.immuni.2025.03.007.
Songnan Wang 1,  Lingyin Li 2
Affiliations

Affiliations

  • 1 Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; ChEM-H Institute, Stanford University, Stanford, CA 94305, USA; Arc Institute, Palo Alto, CA 94304, USA.
  • 2 Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; ChEM-H Institute, Stanford University, Stanford, CA 94305, USA; Arc Institute, Palo Alto, CA 94304, USA. Electronic address: lingyinl@stanford.edu.
PMID: 40203803 DOI: 10.1016/j.immuni.2025.03.007
Abstract

cGAS-cGAMP-STING and OAS-2-5A-RNase L are evolutionarily convergent innate immune pathways. cGAMP acts as an immunotransmitter; what about 2-5A? In this issue of Immunity, Huai et al. map the transfer of 2-5A between cells, establishing it as a bona fide immunotransmitter.

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