2. PROTAC Cell Cycle/DNA Damage Others
  3. Molecular Glues Zinc Finger Protein Drug Derivative
  4. HRZ-01-082-5

HRZ-01-082-5 is an analog of Glutarimide (HY-I0466). HRZ-01-082-5 is a dual-functional molecular glue degrader of SALL4 and OSR1 with a DC50 4.8  nM for OSR1. HRZ-01-082-5 significantly induced SALL4 and OSR1 degradation through CRBN. HRZ-01-082-5 can be used for heart and urogenital development, as well as cancers research.

For research use only. We do not sell to patients.

HRZ-01-082-5

HRZ-01-082-5 Chemical Structure

CAS No. : 3090685-19-8

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Description

HRZ-01-082-5 is an analog of Glutarimide (HY-I0466). HRZ-01-082-5 is a dual-functional molecular glue degrader of SALL4 and OSR1 with a DC50 4.8  nM for OSR1. HRZ-01-082-5 significantly induced SALL4 and OSR1 degradation through CRBN. HRZ-01-082-5 can be used for heart and urogenital development, as well as cancers research[1].

Molecular Weight

530.60

Formula

C27H26N6O4S
CAS No.
SMILES

O=C1NC(C(CC1)N2C(C3=CC=C(C4=C(NC56CC7CC(C6)CC(C5)C7)N8N=CSC8=N4)C=C3C2=O)=O)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HRZ-01-082-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HRZ-01-082-53090685-19-8Molecular GluesZinc Finger ProteinDrug DerivativeDrug derivativeGlutarimideSALL4OSR1CRBNHeart and urogenital developmentCancersInhibitorinhibitorinhibit

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