LZ-07 

LZ-07 is a IRAK4 PROTAC degrader (DC₅₀ = 1.14 nM). LZ-07 leads to marked suppression of cytokines including IL-6, IL-1β, TNF-α, and IL-10 upon degradation of IRAK4. LZ-07 can be studied in research for autoimmune diseases (Pink: IRAK4 ligand (HY-172591); Blue: CRBN ligand (HY-34590); Black: linker (HY-B0149); CRBN ligand + linker: HY-172593)^[1].

LZ-07 (10-100 nM, 16 h) displays the strongest degradation activity with degradation levels exceeding 65% at 10 nM and >75% at 100 nM in THP-1 cells^[1].
LZ-07 (0.3-300 nM, 16 h) demonstrates dose-dependent IRAK4 degradation in DOHH2 and TMD8 cells (DC₅₀ of 1.14 nM and 2.70 nM)^[1].
LZ-07 (0.3-300 nM, 0-24 h) induces rapid and significant degradation within 4 h at 50 nM, achieving maximum degradation at 16 h in TMD8 cells (D_max = 91%) and degrades IRAK4 in DOHH2 cells rapidly^[1].
LZ-07 (30 nM, 8 h) mediates IRAK4 degradation through the ubiquitin-proteasome system and that its activity depends on the binding to both IRAK4 and CRBN^[1].
LZ-07 (3.9-7.6 nM, 2 h) demonstrates superior inhibition of four key inflammatory cytokines (IL-6, IL-10, IL-1β and TNF-α) in LPS (100 ng/mL)-stimulated PBMCs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

812.92

C₄₂H₄₈N₁₄O₄

CC1(CC1)NC2=NC(NC3=CN(C4CCN(C([C@@H]5CC[C@@H](CNC6=CN=C(C(NC7CCC(NC7=O)=O)=O)C=C6)CC5)=O)CC4)N=C3)=NC8=CC=C(C9=CN=CN=C9)N=C82

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhen Li, et al., Developing potent anti-inflammatory IRAK4-targeting PROTACs with simplified CRBN ligands, Chinese Chemical Letters, 2025, 111033, ISSN 1001-8417.