2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. BMS-341400

BMS-341400 is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM. BMS-341400 reduces the degradation of cyclic guanosine monophosphate (cGMP), thereby enhancing nitric oxide (NO)-mediated relaxation of the smooth muscle of the corpus cavernosum and promoting erection. BMS-341400 can be used to study erectile dysfunction.

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BMS-341400

BMS-341400 Chemical Structure

CAS No. : 296250-53-8

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Other Forms of BMS-341400:

BMS-341400 Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

BMS-341400 is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM. BMS-341400 reduces the degradation of cyclic guanosine monophosphate (cGMP), thereby enhancing nitric oxide (NO)-mediated relaxation of the smooth muscle of the corpus cavernosum and promoting erection. BMS-341400 can be used to study erectile dysfunction.

IC50 & Target[1]

PDE5

0.3 nM (IC50)

In Vitro

BMS-341400 (Compound 6) effectively enhanced the relaxation of the smooth muscle in the isolated tissue of the rabbit penile corpus cavernosum, with its EC₅₀ value being 13 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-341400 Related Antibodies
In Vivo

BMS-341400 (Compound 6) (10-1000 nmol/kg, i.v., single dose) effectively promotes the erectile response in the male rabbit model with EC₅₀ value of 100 nmol/kg[1].
BMS-341400 (10-250 mg/kg) demonstrates excellent safety in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Anesthesia-induced male rabbit model[1]
Dosage: 10, 30, 100, 300, and 1000 nmol/kg
Administration: Intravenous injection (i.v.), single dose
Result: Had an equivalent efficacy in promoting erections in the body as Sildenafil (HY-15025).
Molecular Weight

491.93

Formula

C23H22ClN9O2
CAS No.
SMILES

CCN1C2=C(C3=C(C(N4C=C(C(NC)=O)N=C4)=NN=C3NCC5=CC(Cl)=C(OC)C=C5)C=N2)C=N1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BMS-341400 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BMS-341400296250-53-8BMS341400BMS 341400Phosphodiesterase (PDE)RabbitRatsErectile dysfunctionanginaheadacheIntracavernosalBlood pressureInhibitorinhibitorinhibit

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