2. Cell Cycle/DNA Damage
  3. CDK
  4. YY173

YY173 is a dual inhibitor for CDK4 and CDK6 with IC50 of 7.7 and 88 nM. YY173 inhibits the proliferation of cell Jurkat with an IC50 of 1.46 μM. YY173 can be used for synthesis of PROTAC CDK4/6 degrader 1 (HY-163786).

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YY173

YY173 Chemical Structure

CAS No. : 330550-51-1

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YY173 Related Antibodies

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Description

YY173 is a dual inhibitor for CDK4 and CDK6 with IC50 of 7.7 and 88 nM. YY173 inhibits the proliferation of cell Jurkat with an IC50 of 1.46 μM. YY173 can be used for synthesis of PROTAC CDK4/6 degrader 1 (HY-163786)[1].

IC50 & Target

CDK4

7.7 nM (IC50)

CDK6

88 nM (IC50)

Cellular Effect
Cell Line Type Value Description References
Jurkat IC50
1.466 μM
Compound: YY173
Anti-proliferative activity against human Jurkat cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay
Anti-proliferative activity against human Jurkat cells assessed as cell growth inhibition measured after 72 hrs by CCK8 assay
[PMID: 38943626]
Molecular Weight

391.47

Formula

C21H25N7O
CAS No.
SMILES

O=C1N(C2=NC(NC3=CC=C(C=C3)N4CCNCC4)=NC=C2N=C1)C5CCCC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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YY173 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YY173330550-51-1YY 173YY-173CDKCyclin dependent kinaseJurkatdual inhibitorInhibitorinhibitorinhibit

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