2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. HDAC degrader-2

HDAC degrader-2 is a selective HDAC degrader with a DC50 values of 2.55 μM against HDAC1. HDAC degrader-2 effectively induces the degradation of HDAC1 and HDAC2, but has no significant effect on the degradation of HDAC3, 4, 6 and 8. HDAC degrader-2 exerts potent antiproliferative effects against MM.1S and MCF-7 cells. HDAC degrader-2 induces apoptosis in myeloma cells. HDAC degrader-2 can be used for the study of myeloma.

For research use only. We do not sell to patients.

HDAC degrader-2

HDAC degrader-2 Chemical Structure

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HDAC degrader-2 Related Antibodies

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC degrader-2 is a selective HDAC degrader with a DC50 values of 2.55 μM against HDAC1. HDAC degrader-2 effectively induces the degradation of HDAC1 and HDAC2, but has no significant effect on the degradation of HDAC3, 4, 6 and 8. HDAC degrader-2 exerts potent antiproliferative effects against MM.1S and MCF-7 cells. HDAC degrader-2 induces apoptosis in myeloma cells. HDAC degrader-2 can be used for the study of myeloma[1].

IC50 & Target[1]

HDAC1

2.55 μM (DC50)

HDAC2

 

In Vitro

HDAC-degrader 2 (Compound SZ-2) (24 h) exerted potent antiproliferative effects against MM.1S (IC50 = 3.28 μM) and MCF-7 (IC50 = 3.46 μM) cells[1].
HDAC-degrader 2 (5 μM, 48 h) significantly induces apoptosis in MM.1S cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC degrader-2 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MM.1S cells
Concentration: 5 μM
Incubation Time: 48 h
Result: Significantly increased the percentages of early and late apoptotic cells.
Molecular Weight

591.10

Formula

C32H35ClN4O5
SMILES

O=C(NCCCCCCC(NO)=O)C1=CC=C(C2CC(C3=CC=CC(OCC4=CC=CC=C4)=C3)=NN2C(CCl)=O)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC degrader-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC degrader-2HDAC degrader2HDAC degrader 2HDACApoptosisHistone deacetylasesHistone deacetylase (HDAC)CancerDamage-specific DNA binding protein 1 (DDB1)Proteolysis targeting chimeras (PROTACs)Targeted Protein Degradation (TPD)Inhibitorinhibitorinhibit

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HDAC degrader-2
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