2. PROTAC
  3. Ligands for Target Protein for PROTAC
  4. JYQ-173

JYQ-173 is a selective inhibitor for human Parkinson disease protein 7 (PARK7), with an IC50 of 19 nM. JYQ-173 exhibits good cell permeability. JYQ-173 is the ligand for target protein PARK7, which can be utilized for synthesis of PROTAC Degrader JYQ-194 (HY-163564).

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JYQ-173 Chemical Structure

JYQ-173 Chemical Structure

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Based on 1 publication(s) in Google Scholar

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Description

JYQ-173 is a selective inhibitor for human Parkinson disease protein 7 (PARK7), with an IC50 of 19 nM. JYQ-173 exhibits good cell permeability. JYQ-173 is the ligand for target protein PARK7, which can be utilized for synthesis of PROTAC Degrader JYQ-194 (HY-163564)[1].

IC50 & Target

IC50: 19 nM (PARK7)
Molecular Weight

466.49

Formula

C21H19FN8O2S
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@H]1CN(C#N)CC1)NC(S2)=NC3=C2CN(C(C4=C(F)C=CC(N5C=CN=N5)=C4)=O)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (214.37 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1437 mL 10.7183 mL 21.4367 mL
5 mM 0.4287 mL 2.1437 mL 4.2873 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1437 mL 10.7183 mL 21.4367 mL 53.5917 mL
5 mM 0.4287 mL 2.1437 mL 4.2873 mL 10.7183 mL
10 mM 0.2144 mL 1.0718 mL 2.1437 mL 5.3592 mL
15 mM 0.1429 mL 0.7146 mL 1.4291 mL 3.5728 mL
20 mM 0.1072 mL 0.5359 mL 1.0718 mL 2.6796 mL
25 mM 0.0857 mL 0.4287 mL 0.8575 mL 2.1437 mL
30 mM 0.0715 mL 0.3573 mL 0.7146 mL 1.7864 mL
40 mM 0.0536 mL 0.2680 mL 0.5359 mL 1.3398 mL
50 mM 0.0429 mL 0.2144 mL 0.4287 mL 1.0718 mL
60 mM 0.0357 mL 0.1786 mL 0.3573 mL 0.8932 mL
80 mM 0.0268 mL 0.1340 mL 0.2680 mL 0.6699 mL
100 mM 0.0214 mL 0.1072 mL 0.2144 mL 0.5359 mL
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JYQ-173 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JYQ-173JYQ173JYQ 173Ligands for Target Protein for PROTACTarget Protein-binding MoietyUbiquitinationDegradationCancerNeurodegenerative DiseasesParkinson's diseaseA549Inhibitorinhibitorinhibit

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