PROTAC FLT-3 degrader 3

Cat. No.: HY-161280: Data Sheet Handling Instructions
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PROTAC FLT-3 degrader 3 (compound 35) is a PROTACs degrader of FLT. PROTAC FLT-3 degrader 3 has antiproliferative activity, with IC₅₀ of 7.55 nM in MV4-11 cells.

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PROTAC FLT-3 degrader 3 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

PROTAC FLT-3 degrader 3 (compound 35) is a PROTACs degrader of FLT. PROTAC FLT-3 degrader 3 has antiproliferative activity, with IC₅₀ of 7.55 nM in MV4-11 cells^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 10000 nM Compound: 35	Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human A549 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 38387337]
LoVo	IC₅₀	> 10000 nM Compound: 35	Antiproliferative activity against human LoVo cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human LoVo cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 38387337]
MDA-MB-231	IC₅₀	6482 nM Compound: 35	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 38387337]
MOLM-13	IC₅₀	18.23 nM Compound: 35	Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 38387337]
MV4-11	IC₅₀	7.55 nM Compound: 35	Antiproliferative activity against human MV4-11 cells expressing FLT3 ITD mutant assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human MV4-11 cells expressing FLT3 ITD mutant assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 38387337]
NCI-N87	IC₅₀	> 10000 nM Compound: 35	Antiproliferative activity against human NCI-N87 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human NCI-N87 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 38387337]
Panc02	IC₅₀	> 10000 nM Compound: 35	Antiproliferative activity against mouse Panc02 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against mouse Panc02 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 38387337]
U-937	IC₅₀	> 10000 nM Compound: 35	Antiproliferative activity against human U-937 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay Antiproliferative activity against human U-937 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay	[PMID: 38387337]

Molecular Weight

927.83

Formula

C₄₈H₄₄Cl₂N₁₀O₆

SMILES

O=C1C(CCC(N1)=O)N(C2=O)C(C3=C2C(N4CCN(C(CC5CCN(C6=CC=C(C(NC7=NNC(C8=CC(N(CC9=C(Cl)C=CC=C9Cl)C=N%10)=C%10C=C8)=C7)=O)C=C6)CC5)=O)CC4)=CC=C3)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhijie Wang, et al. Discovery of FLT3-targeting PROTACs with potent antiproliferative activity against acute myeloid leukemia cells harboring FLT3 mutations. Eur J Med Chem. 2024 Feb 14:268:116237. [Content Brief]