2. Epigenetics Immunology/Inflammation GPCR/G Protein
  3. Histone Acetyltransferase Interleukin Related CXCR
  4. GSK699

GSK699 is a PCAF/GCN5 PROTAC degrader. GSK699 promotes the ubiquitination and degradation of PCAF/GCN5. GSK699 inhibits the production of cytokines/chemokines (e.g., IL-6, CXCL1/GROα). GSK699 can be used in the research of inflammatory diseases (target protein ligand: HY-101027, CRBN ligand: HY-103596).

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GSK699

GSK699 Chemical Structure

CAS No. : 2260944-68-9

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GSK699 Related Antibodies

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Description

GSK699 is a PCAF/GCN5 PROTAC degrader. GSK699 promotes the ubiquitination and degradation of PCAF/GCN5. GSK699 inhibits the production of cytokines/chemokines (e.g., IL-6, CXCL1/GROα). GSK699 can be used in the research of inflammatory diseases (target protein ligand: HY-101027, CRBN ligand: HY-103596)[1][2].

IC50 & Target[1][2]

IL-6

 

GCN5/PCAF

 

Molecular Weight

895.84

Formula

C45H51BrN8O7
CAS No.
SMILES

O=C(N(CCCN(C1=CC=C(CCCOC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)C=C1)C)C)C5=CC=C([C@@H]6CN(C)C[C@H](NC(C=NN7C)=C(Br)C7=O)C6)C=C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GSK699 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK6992260944-68-9GSK 699GSK-699Histone AcetyltransferaseInterleukin RelatedCXCRHATsHATILCXC chemokine receptorsC-X-C motif chemokine receptorsMacrophagesDCsanti-inflammatorydendritic cells.Inhibitorinhibitorinhibit

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