2. PROTAC Cell Cycle/DNA Damage Epigenetics Immunology/Inflammation
  3. PROTACs PARP Interleukin Related
  4. RBN012811

RBN012811 is a selectively PARP14 PROTAC degrader with a DC50 of 5 nM in KYSE-270 cells. RBN012811 significantly decreases IL-10 expression in IL-4 stimulated macrophages. Pink: PARP14 ligand (HY-150947); Blue: CRBN ligase ligand (HY-10984); Black: linker

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RBN012811

RBN012811 Chemical Structure

CAS No. : 2569517-30-0

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RBN012811 Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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Description

RBN012811 is a selectively PARP14 PROTAC degrader with a DC50 of 5 nM in KYSE-270 cells. RBN012811 significantly decreases IL-10 expression in IL-4 stimulated macrophages[1]. Pink: PARP14 ligand (HY-150947); Blue: CRBN ligase ligand (HY-10984); Black: linker

IC50 & Target[1]

PARP14

5 (KYSE-27 nM (DC50)

IL-10

 

Molecular Weight

788.93

Formula

C40H49FN8O6S
CAS No.
Appearance

Solid

SMILES

O=C1N=C(CSC2CCN(CC2)CC(NCCCCCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)NC6=CC(NC7CCCC7)=CC(F)=C16
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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RBN012811 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RBN0128112569517-30-0RBN 012811RBN-012811PROTACsPARPInterleukin Relatedpoly ADP ribose polymerase ILPROTACDegradationPARP14MacrophagesKYSE-270 cellsMDA-MB-231 cellsJJN-3 cells293T cellsInhibitorinhibitorinhibit

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