2. PROTAC Epigenetics
  3. PROTACs Epigenetic Reader Domain
  4. DBr-1

DBr-1 is a potent BRD9 PROTAC degrader (KD: 13 nM). DBr-1 can overcome intrinsic resistance to VHL-degrader. Blue: DCAF1 binder (HY-149934), Black: linker, Pink: BRD9/BRD7 bromodomains inhibitor (HY-100352).

For research use only. We do not sell to patients.

DBr-1 Chemical Structure

DBr-1 Chemical Structure

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Based on 1 publication(s) in Google Scholar

DBr-1 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • Biological Activity

  • Purity & Documentation

  • References

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Description

DBr-1 is a potent BRD9 PROTAC degrader (KD: 13 nM). DBr-1 can overcome intrinsic resistance to VHL-degrader. Blue: DCAF1 binder (HY-149934), Black: linker, Pink: BRD9/BRD7 bromodomains inhibitor (HY-100352)[1].

Molecular Weight

970.64

Formula

C55H68ClN9O5
Appearance

Solid

Color

Off-white to light yellow

SMILES

COC1=C(C(C2=C3C=NC=C2)=CN(C)C3=O)C=C(OC)C(CN4CCC(OCCCCCC(N5CCN(C6=CC=C7C(N=C(C8(C9=CC=C(Cl)C=C9)CCCCC8)N=C7NCCN)=C6)CC5)=O)CC4)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (103.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0302 mL 5.1512 mL 10.3025 mL
5 mM 0.2060 mL 1.0302 mL 2.0605 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0302 mL 5.1512 mL 10.3025 mL 25.7562 mL
5 mM 0.2060 mL 1.0302 mL 2.0605 mL 5.1512 mL
10 mM 0.1030 mL 0.5151 mL 1.0302 mL 2.5756 mL
15 mM 0.0687 mL 0.3434 mL 0.6868 mL 1.7171 mL
20 mM 0.0515 mL 0.2576 mL 0.5151 mL 1.2878 mL
25 mM 0.0412 mL 0.2060 mL 0.4121 mL 1.0302 mL
30 mM 0.0343 mL 0.1717 mL 0.3434 mL 0.8585 mL
40 mM 0.0258 mL 0.1288 mL 0.2576 mL 0.6439 mL
50 mM 0.0206 mL 0.1030 mL 0.2060 mL 0.5151 mL
60 mM 0.0172 mL 0.0859 mL 0.1717 mL 0.4293 mL
80 mM 0.0129 mL 0.0644 mL 0.1288 mL 0.3220 mL
100 mM 0.0103 mL 0.0515 mL 0.1030 mL 0.2576 mL
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DBr-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DBr-1DBr1DBr 1PROTACsEpigenetic Reader DomainInhibitorinhibitorinhibit

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