2. PROTAC Metabolic Enzyme/Protease
  3. Ligands for Target Protein for PROTAC Fat Mass and Obesity-associated Protein (FTO)
  4. FTO ligand-1

FTO ligand-1 is a FTO ligand for FTO PROTAC degrader FP54 (HY-175885). FTO ligand-1 can inhibit cell proliferation and block the FP54-induced FTO degradation. FTO ligand-1 can be used for research of cancer, such as acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

FTO ligand-1

FTO ligand-1 Chemical Structure

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FTO ligand-1 Related Antibodies

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Description

FTO ligand-1 is a FTO ligand for FTO PROTAC degrader FP54 (HY-175885). FTO ligand-1 can inhibit cell proliferation and block the FP54-induced FTO degradation. FTO ligand-1 can be used for research of cancer, such as acute myeloid leukemia (AML)[1].

In Vitro

FTO ligand-1 shows anti-proliferative activity in NB4 cells with an EC50 of 19 μM[1].
FTO ligand-1 (0.4-10 μM, 2 h) dose-dependently blocks the FP54 (HY-175885)-induced FTO degradation in NB4 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FTO ligand-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: NB4 cells
Concentration: 0.4, 2 and 10 μM, companied with FP54 (HY-175885) (2 μM)
Incubation Time: 2 h
Result: Dose-dependently blocked the FP54 (HY-175885)-induced FTO degradation.
Molecular Weight

561.46

Formula

C27H30Cl2N4O5
SMILES

ClC1=C(NC2=CC=CC(N3CCNCC3)=C2C(OCOC(C(C)C)=O)=O)C(Cl)=CC(C4=C(C)ON=C4C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FTO ligand-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FTO ligand-1FTO ligand1FTO ligand 1Ligands for Target Protein for PROTACFat Mass and Obesity-associated Protein (FTO)Target Protein-binding MoietyPROTACFTOAMLNB4Inhibitorinhibitorinhibit

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