2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. KVA-D-88

KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 and 880 nM for PDE4B and PDE4D, respectively. KVA-D-88 has the ability to inhibit cocaine-induced hyperlocomotor activity and sensitization. KVA-D-88 selectively inhibits PDE4B and reduces cAMP degradation, thereby modulating neuroadaptive responses. KVA-D-88 can be used in the study of cocaine addiction.

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KVA-D-88 Chemical Structure

KVA-D-88 Chemical Structure

CAS No. : 2410550-31-9

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KVA-D-88 Related Antibodies

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Description

KVA-D-88 is a blood-brain barrier-permeable PDE4 inhibitor with IC50 values of 140 and 880 nM for PDE4B and PDE4D, respectively. KVA-D-88 has the ability to inhibit cocaine-induced hyperlocomotor activity and sensitization. KVA-D-88 selectively inhibits PDE4B and reduces cAMP degradation, thereby modulating neuroadaptive responses. KVA-D-88 can be used in the study of cocaine addiction[1].

IC50 & Target[1]

PDE4B

140 nM (IC50)

PDE4D

880 nM (IC50)

Molecular Weight

382.19

Formula

C17H11Cl2F2N3O
CAS No.
Appearance

Solid

SMILES

O=C(C1=CC2=CC=CN=C2N1C3=CC=C(Cl)C(Cl)=C3)N4CC(F)(F)C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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KVA-D-88 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KVA-D-882410550-31-9Phosphodiesterase (PDE)PDEcocainedrug addictioncAMPWT miceC57BL/6J miceInhibitorinhibitorinhibit

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