2. Apoptosis PROTAC
  3. Bcl-2 Family PROTACs
  4. PROTAC BCL-xL/BCL-w Degrader 1

PROTAC BCL-xL/BCL-w Degrader 1 (Compound 44) is a BCL-xL/BCL-w PROTAC degrader. PROTAC BCL-xL/BCL-w Degrader 1 has significant anticancer activity with reduced on-target platelet toxicity . Pink: BCL-xL/BCL-w ligand (HY-10087); Blue: CRBN ligase ligand (HY-163233); Black: linker (HY-Y1230)

For research use only. We do not sell to patients.

PROTAC BCL-xL/BCL-w Degrader 1

PROTAC BCL-xL/BCL-w Degrader 1 Chemical Structure

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PROTAC BCL-xL/BCL-w Degrader 1 Related Antibodies

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Description

PROTAC BCL-xL/BCL-w Degrader 1 (Compound 44) is a BCL-xL/BCL-w PROTAC degrader. PROTAC BCL-xL/BCL-w Degrader 1 has significant anticancer activity with reduced on-target platelet toxicity [1]. Pink: BCL-xL/BCL-w ligand (HY-10087); Blue: CRBN ligase ligand (HY-163233); Black: linker (HY-Y1230)

IC50 & Target[1]

Bcl-xL

 

Bcl-W

 

Molecular Weight

1381.05

Formula

C69H77ClF3N9O10S3
SMILES

ClC(C=C1)=CC=C1C2=C(CN3CCN(C4=CC=C(C(NS(=O)(C5=CC(S(C(F)(F)F)(=O)=O)=C(N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)C(C#CCCC(N8CCN(C9=CC=C(C(N(C%10CCC(NC%10=O)=O)C%11)=O)C%11=C9)CC8)=O)=C5)=O)=O)C=C4)CC3)CC(C)(C)CC2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC BCL-xL/BCL-w Degrader 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC BCL-xL/BCL-w Degrader 1Bcl-2 FamilyPROTACsPROTACDegradationBCL-xL/BCL-wAnticancerPlatelet toxicityMOLT-4 cellsRS4;11 cellsHeLa cellsInhibitorinhibitorinhibit

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