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4,4'-Dihydroxybiphenyl-d<sub>8</sub>

" in MedChemExpress (MCE) Product Catalog:

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Oligonucleotides:	A (12) Solvents (1) Nucleosides and their Analogs (51) Preservatives (1) C (11) Nucleoside Phosphoramidites (6) G (5) Rat Pre-designed siRNA Sets (9) I (3) Solubilizing Agents (1) siRNA drugs (1) siRNAs (44) T (4) U (22) Emulsifiers (1) Mouse Pre-designed siRNA Sets (10) Cationic Lipids (1) Adjuvant (1) Human Pre-designed siRNA Sets (24)

7480

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

422

Biochemical Assay Reagents

173

Peptides

MCE Kits

Inhibitory Antibodies

461

Natural
Products

Recombinant Proteins

4513

Isotope-Labeled Compounds

Antibodies

Click Chemistry

106

Oligonucleotides

Targets Recommended: CD44 P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011927S

4,4'-Sulfonyldiphenol-d8 1 Publications Verification Bisphenol S (4,4'-Sulfonyldiphenol)-d<sub>8sub>	Isotope-Labeled Compounds	Others
4,4'-Sulfonyldiphenol-d₈ is the deuterium labeled 4,4'-Sulfonyldiphenol .

HY-W016189S

4,4'-Dihydroxybiphenyl-d8	Isotope-Labeled Compounds	Others
4,4'-Dihydroxybiphenyl-d₈ is the deuterium labeled 4,4'-Dihydroxybiphenyl .

HY-B1955S

4',4-Dibromobiphenyl-d8 NSC 2098-d<sub>8sub>; PBB 15-d<sub>8sub>; p,p'-Dibromobiphenyl-d<sub>8sub>	Isotope-Labeled Compounds	Others
4',4-Dibromobiphenyl-d₈ is the deuterium labeled 4',4-Dibromobiphenyl[1].

HY-B1986S

p,p'-DDE-d8 4,4'-DDE-d<sub>8sub>; p,p'-Dichlorodiphenyldichloroethylene-d<sub>8sub>	Androgen Receptor Drug Metabolite	Endocrinology
p,p'-DDE-d₈ is the deuterium labeled p,p'-DDE . p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC₅₀ of 5 μM and a K_i of 3.5 μM .

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-RS18793

Sub1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Mouse Pre-designed siRNA Set A Sub1 Mouse Pre-designed siRNA Set A

HY-RS25282

Sub1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Rat Pre-designed siRNA Set A Sub1 Rat Pre-designed siRNA Set A

HY-W767978

*1-(4,4-Dimethylthiochroman-6-yl)ethanone-d8* 6-Acetyl-4,4-dimethylthio-chroman-d<sub>8sub>	Isotope-Labeled Compounds	Others
1-(4,4-Dimethylthiochroman-6-yl)ethanone-d₈ (6-Acetyl-4,4-dimethylthio-chroman-d₈) is the deuterium labeled 1-(4,4-Dimethylthiochroman-6-yl)ethanone (HY-I0187).

HY-W777094

*1-Acetyl-4-(4-hydroxyphenyl)piperazine-d8* Tetraethoxy C methyl propane-d<sub>8sub>	Isotope-Labeled Compounds	Others
1-Acetyl-4-(4-hydroxyphenyl)piperazine-d₈ (Tetraethoxy C methyl propane-d₈) is the deuterium labeled 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone (HY-W014037).

HY-B1984S

p,p'-DDD-d8 4,4'-DDD-d<sub>8sub>; p,p'-Dichlorodiphenyl dichloroethane-d<sub>8sub>	Drug Metabolite Apoptosis Necroptosis Insecticide	Infection Neurological Disease Cancer
p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

HY-W653930

4,4'-Sulfonyldiphenol-13C12 Bisphenol S-¹³C<sub>12sub>; Bis(4-hydroxyphenyl) sulfone-¹³C<sub>12sub>	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
4,4'-Sulfonyldiphenol- ¹³C₁₂ (Bisphenol S- ¹³C₁₂) is ¹³C labeled 4,4'-Sulfonyldiphenol. 4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-W024986S

4-(4-Hexoxyphenyl)benzonitrile-13C6 4'-Hexyloxy-4-biphenylcarbonitrile-¹³C<sub>6sub>	Isotope-Labeled Compounds	Others
4-(4-Hexoxyphenyl)benzonitrile- ¹³C₆ (4'-Hexyloxy-4-biphenylcarbonitrile- ¹³C₆) is the ¹³C-labeled 4-(4-Hexoxyphenyl)benzonitrile.

HY-W699637

4-[[(4-Fluorophenyl)imino]methyl]phenol-d4 4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol-d<sub>4sub>	Isotope-Labeled Compounds	Others
4-[[(4-Fluorophenyl)imino]methyl]phenol-d₄ (4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol-d₄) is the deuterium labeled 4-[[(4-Fluorophenyl)imino]methyl]phenol (HY-W014178).

HY-B0688S

Dapsone-d8 4,4′-Diaminodiphenyl sulfone-d<sub>8sub>; DDS-d<sub>8sub>	Antibiotic Parasite Bacterial Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology Cancer
Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases .

HY-W142647S

*2,2'-Dihydroxy-4,4'-dimethoxybenzophenone-d6* Bis(2-hydroxy-4-methoxyphenyl)methanone-d<sub>6sub>	Isotope-Labeled Compounds	Others
2,2'-Dihydroxy-4,4'-dimethoxybenzophenone-d₆ (Bis(2-hydroxy-4-methoxyphenyl)methanone-d₆) is deuterium labeled 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone .

HY-W242724

*1,4-Dibromo-butane-1,1,2,2,3,3,4,4-d8* 1,4-Dibromobutane-d<sub>8sub>; Tetramethylene Bromide-d<sub>8sub>	Isotope-Labeled Compounds	Others
1,4-Dibromo-butane-1,1,2,2,3,3,4,4-d₈ is the deuterium labeled 1,4-Dibromo-butane .

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-N0067S2

*γ-Aminobutyric acid-4,4-d2* 4-Aminobutyric acid-4,4-d<sub>2sub>	Isotope-Labeled Compounds GABA Receptor Endogenous Metabolite	Neurological Disease
γ-Aminobutyric acid-4,4-d₂ is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].

HY-B0688S3

Dapsone-15N2 4,4′-Diaminodiphenyl sulfone-¹⁵N<sub>2sub>; DDS-¹⁵N<sub>2sub>	Isotope-Labeled Compounds Antibiotic Reactive Oxygen Species (ROS) Bacterial Parasite	Infection Inflammation/Immunology
Dapsone- ¹⁵N₂ (4,4′-Diaminodiphenyl sulfone- ¹⁵N₂) is ¹⁵N labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-W654082

Bisphenol e-13C6 4,4'-Ethylidenediphenol-¹³C<sub>6sub>	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
Bisphenol e- ¹³C₆ is ¹³C labeled Bisphenol E. Bisphenol E (4,4'-Ethylidenediphenol) is a biochemical reagent .

HY-42118S

4-(4-Fluorobenzylamino)-1-methylpiperidine-d2 N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine-d<sub>2sub>; (4-Fluoro-benzyl)-(1-methyl-piperidin-4-yl)-amine-d<sub>2sub>	Isotope-Labeled Compounds	Others
4-(4-Fluorobenzylamino)-1-methylpiperidine-d₂ (N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine-d₂) is the deuterium labeled 4-(4-Fluorobenzylamino)-1-methylpiperidine.

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Parasite	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent **Plasmodium subtilisin-like protease 1 (SUB1)** inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

HY-W751537

4-[[(4-Fluorophenyl)imino]methyl]phenol-13C6 4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol-¹³C<sub>6sub>	Isotope-Labeled Compounds	Others
4-[[(4-Fluorophenyl)imino]methyl]phenol- ¹³C₆ (4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol- ¹³C₆) is the ¹³C-labeled 4-[[(4-Fluorophenyl)imino]methyl]phenol (HY-W014178).

HY-B0688S1

Dapsone-d4 4,4′-Diaminodiphenyl sulfone-d<sub>4sub>; DDS-d<sub>4sub>	Isotope-Labeled Compounds Antibiotic Parasite Bacterial Reactive Oxygen Species (ROS)	Infection Inflammation/Immunology
Dapsone-d₄ is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-W009293S

1-(Bis(4-fluorophenyl)methyl)piperazine-d4 N-(4,4-Difluorobenzhydryl)piperazine-d<sub>4sub>	Isotope-Labeled Compounds	Others
1-(Bis(4-fluorophenyl)methyl)piperazine-d₄ (N-(4,4-Difluorobenzhydryl)piperazine-d₄) is the deuterium labeled 1-(Bis(4-fluorophenyl)methyl)piperazine.

HY-12085S1

Apremilast-d8 CC-10004-d<sub>8sub>	Isotope-Labeled Compounds Apoptosis TNF Receptor Phosphodiesterase (PDE)	Inflammation/Immunology
Apremilast-d₈ (CC-10004-d₈) is deuterium labeled Apremilast. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM .

HY-W740498

Raspberry ketone-d5 Frambione-d<sub>5sub>; 4-(4-Hydroxyphenyl)-2-butanone-d<sub>5sub>	Isotope-Labeled Compounds PPAR	Metabolic Disease
Raspberry ketone-d₅ (Frambione-d₅; 4-(4-Hydroxyphenyl)-2-butanone-d₅) is the deuterium labeled Raspberry ketone (HY-N1426). Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff; also shows PPAR-α agonistic activity.

HY-103332S

N-Arachidonylglycine-d8 NA-Gly-d<sub>8sub>	Isotope-Labeled Compounds Endogenous Metabolite GlyT	Inflammation/Immunology
N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine . N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC₅₀ = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC₅₀ = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .

HY-14806S

Teneligliptin-d8 MP-513 d<sub>8sub>	Dipeptidyl Peptidase	Cardiovascular Disease
Teneligliptin-d₈ is a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor .

HY-17037S1

Pirenzepine-d8 dihydrochloride LS 519-d<sub>8sub> dihydrochloride; Pirenzepin-d<sub>8sub> dihydrochloride; Gastrozepin-d<sub>8sub> dihydrochloride	Isotope-Labeled Compounds mAChR	Cancer
Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-G0021S

N-Desmethylclozapine-d8 Norclozapine-d<sub>8sub>; Desmethylclozapine-d<sub>8sub>; Normethylclozapine-d<sub>8sub>	mAChR Opioid Receptor Drug Metabolite Virus Protease	Infection
N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC₅₀=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist .

HY-G0021S1

N-Desmethylclozapine-d8 hydrochloride Norclozapine-d<sub>8sub> hydrochloride; Desmethylclozapine-d<sub>8sub> hydrochloride; Normethylclozapine-d<sub>8sub> hydrochloride	mAChR Opioid Receptor Drug Metabolite Virus Protease	Infection
N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC₅₀=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist .

HY-B0615AS

Moricizine-d8(Hydrochloride) EN 313-d<sub>8sub>; Ethmozin-d<sub>8sub>; Moracizine-d<sub>8sub>	Isotope-Labeled Compounds	Cardiovascular Disease
Moricizine-d₈ (Hydrochloride) is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period .

HY-W748758

(Z)-Thiothixene-d8 NSC 108165-d<sub>8sub>; Navan-d<sub>8sub>; Navane-d<sub>8sub>	Isotope-Labeled Compounds Dopamine Receptor Histamine Receptor mAChR Adrenergic Receptor Sigma Receptor	Others
(Z)-Thiothixene-d₈ (NSC 108165-d₈; Navan-d₈; Navane-d₈) is the deuterium labeled Thiothixene (HY-A0139). Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.

HY-W753141

p,p'-DDE-13C12 4,4'-DDE-¹³C<sub>12sub>; p,p'-Dichlorodiphenyldichloroethylene-¹³C<sub>12sub>	Isotope-Labeled Compounds Androgen Receptor Drug Metabolite	Endocrinology
p,p'-DDE- ¹³C₁₂ is ¹³C labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC₅₀ of 5 μM and a K_i of 3.5 μM .

HY-W018811

Antibacterial agent 268	Bacterial	Infection
Antibacterial agent 268 (Compound 10e) is an antibacterial agent with antimycobacterial properties. Antibacterial agent 268 shows high anti-bacterial properties at sub-micromolar values (MIC=0.44-0.07 μM) .

HY-50896S3

Erlotinib-d8 CP-358774-d<sub>8sub>; NSC 718781-d<sub>8sub>; OSI-774-d<sub>8sub>	Isotope-Labeled Compounds	Cancer
Erlotinib-d₈ (CP-358774-d₈) is deuterium labeled Erlotinib. Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC₅₀ of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC₅₀ of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer . Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14740S

Elvitegravir-d8 GS-9137-d<sub>8sub>; JTK-303-d<sub>8sub>; D06677-d<sub>8sub>	Isotope-Labeled Compounds HIV Integrase HIV	Infection
Elvitegravir-d₈ is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-17037S

Pirenzepine-d8 LS 519-d<sub>8sub> free base; Pirenzepin-d<sub>8sub>; Gastrozepin-d<sub>8sub>	Isotope-Labeled Compounds mAChR	Neurological Disease Inflammation/Immunology
Pirenzepine-d₈ is the deuterium labeled Pirenzepine dihydrochloride. Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.

HY-10227S

Bortezomib-d8 PS-341-d<sub>8sub>; LDP-341-d<sub>8sub>; NSC 681239-d<sub>8sub>	Proteasome NF-κB Apoptosis Autophagy	Cancer
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity .

HY-10570S2

Nevirapine-d8 BI-RG 587-d<sub>8sub>; NSC 641530-d<sub>8sub>; NVP-d<sub>8sub>	Isotope-Labeled Compounds Reverse Transcriptase Parasite HIV	Infection Cancer
Nevirapine-d₈ (BI-RG 587-d₈) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-15531S

Venetoclax-d8 ABT-199-d<sub>8sub>; GDC-0199-d<sub>8sub>; RG7601-d<sub>8sub>	Bcl-2 Family Autophagy	Cancer
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy .

HY-13463BS

Avatrombopag-d8 hydrochloride AKR-501-d<sub>8sub> hydrochloride; E5501-d<sub>8sub> hydrochloride; YM477-d<sub>8sub> hydrochloride	Isotope-Labeled Compounds Thrombopoietin Receptor	Cardiovascular Disease
Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-13011S

Alectinib-d8 CH5424802-d<sub>8sub>; RO5424802-d<sub>8sub>; AF802-d<sub>8sub>	Isotope-Labeled Compounds Anaplastic lymphoma kinase (ALK)	Cancer
Alectinib-d₈ is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC₅₀ of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC₅₀s of 1 nM and 3.5 nM, respectively . Alectinib demonstrates effective central nervous system (CNS) penetration .

HY-15581S

MMAD-d8 Demethyldolastatin 10-d<sub>8sub>; Monomethylauristatin D-d<sub>8sub>; Monomethyl Dolastatin 10-d<sub>8sub>	ADC Payload Microtubule/Tubulin	Cancer
MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

HY-Y1309S

1-Naphthol-d8 Furro ER-d<sub>8sub>; NSC 9586-d<sub>8sub>; Nako TRB-d<sub>8sub>	Endogenous Metabolite	Others
1-Naphthol-d₈ is the deuterium labeled 1-Naphthol . 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe .

HY-W771024

Butane-1,4-diyl bis(4-methylbenzenesulfonate)-13C4 4-(4-Methylphenyl)sulfonyloxybutyl 4-methylbenzenesulfonate-¹³C<sub>4sub>; NSC 521542-¹³C<sub>4sub>	Isotope-Labeled Compounds	Others
Butane-1,4-diyl bis(4-methylbenzenesulfonate)- ¹³C₄ (4-(4-Methylphenyl)sulfonyloxybutyl 4-methylbenzenesulfonate- ¹³C₄) is the ¹³C-labeled Butane-1,4-diyl bis(4-methylbenzenesulfonate) (HY-Z1250).

HY-N0378S

D-Mannitol-d8 Mannitol-d<sub>8sub>; Mannite-d<sub>8sub>	Endogenous Metabolite Apoptosis	Metabolic Disease
D-Mannitol-d₈ is the deuterium labeled D-Mannitol. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.

HY-13502S

Mitoxantrone-d8 Mitozantrone-d<sub>8sub>; NSC 301739-d<sub>8sub>	Isotope-Labeled Compounds Topoisomerase PKC	Cancer
Mitoxantrone-d₈ (mitozantrone-d₈) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-136064

4,4'-Dimethoxychalcone 1 Publications Verification	Structural Classification Chalcones Flavonoids other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	Autophagy
4,4'-Dimethoxychalcone acts as a natural autophagy inducer with anti-ageing properties .

HY-N7171

4,4'-Di-O-methylellagic acid 4,4'-DiOMEA; Nasutin C	Structural Classification Animals Source classification Phenols Polyphenols	Wnt
4,4'-Di-O-methylellagic acid (4,4'-DiOMEA; Nasutin C) can be isolated from the Australian termites. 4,4'-Di-O-methylellagic acid is blue-fluorescent under ultra-violet light . 4,4'-Di-O-methylellagic acid inhibits colon cancer cell proliferation via the wnt signal pathway .

HY-Y0035R

4,4-Dimethoxy-2-butanone (Standard)	Structural Classification Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite
4,4-Dimethoxy-2-butanone (Standard) is the analytical standard of 4,4-Dimethoxy-2-butanone. This product is intended for research and analytical applications. 4,4-Dimethoxy-2-butanone is an endogenous metabolite.

HY-N15380

4,4′-Secalonic acid D	Structural Classification Xanthones Animals Source classification Phenols	PARP Reactive Oxygen Species (ROS) Caspase Apoptosis Pyroptosis
4,4′-Secalonic acid D (Compound 12) is a PARP1 inhibitor. 4,4′-Secalonic acid D induces the accumulation of ROS and DNA damage, activates the caspase-3/GSDME pathway, and triggers apoptosis and pyroptosis of tumor cells by inhibiting PARP1. 4,4′-Secalonic acid D has anti-tumor activity .

HY-N14302

44-Homooligomycin A	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
44-HomooIigomycin A is an antitumor antibiotic. 44-Homooligomycin A has activity against fungi such as Aspergillus, Penicillium and Fusarium, but not against yeast and bacteria. 44-Homooligomycin A has moderate anti-tumor activity against Colon 26 in vivo .

HY-N14305

44-Homooligomycin B	Structural Classification Natural Products Microorganisms Source classification	Antibiotic Bacterial
44-HomooIigomycin B is an antitumor antibiotic. 44-Homooligomycin B has activity against fungi such as Aspergillus, Penicillium and Fusarium, but not against yeast and bacteria. 44-Homooligomycin B has moderate anti-tumor activity against Colon 26 in vivo .

HY-W720006

4,4'-Diapo-ω,ω-carotene-4,4'-dial	Structural Classification Natural Products Source classification Araucariaceae Plants Araucaria cunninghamii Mudie	Drug Derivative
4,4'-Diapo-ω,ω-carotene-4,4'-dial is a carotenoid pigment. Carotenoids are important biological active, and may regulate cellular differentiation, growth control, photooxidative protection, cell membrane stability, photosynthesis, vision process and nutrition .

HY-125833R

Alpha-Naphthoflavone (Standard)	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone (Standard) is the analytical standard of Alpha-Naphthoflavone. This product is intended for research and analytical applications. Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis .

HY-N11796

Anti-inflammatory agent 44	Structural Classification Flavonoids Flavones Source classification Phenols Polyphenols Aizoaceae Plants Tetragonia tetragonioides (Pall.) Kuntze	Biochemical Assay Reagents
Anti-inflammatory agent 44 (compound 1) is a 6-methoxyflavonol glycoside, with anti-inflammatory activity. Anti-inflammatory agent 44 can be isolated from the aerial parts of Tetragonia tetragonoides .

HY-N9225

4',4'''-Di-O-methylisochamaejasmin	Flavonoids Classification of Application Fields Thymelaeaceae Source classification Phenols Polyphenols Plants Biflavones Disease Research Fields Cancer Stellera chamaejasme L.	Others
4',4'''-Di-O-methylisochamaejasminexhibits anti-cancer effect .

HY-Y0035

4,4-Dimethoxy-2-butanone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4,4-Dimethoxy-2-butanone is an endogenous metabolite.

HY-W009390A

4,4'-Disulfanediylbis(2-aminobutanoic acid)	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
4,4'-Disulfanediylbis(2-aminobutanoic acid) is an endogenous metabolite.

HY-N1877

4',4'''-Di-O-methylcupressuflavone	Structural Classification Flavonoids Phyllanthaceae Source classification Phyllanthus sellowianus (Klotzsch) Müll.Arg. Plants Biflavones	Others
4',4'''-Di-O-methylcupressuflavone can be isolated from Phyllanthus sellmianus .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N9257

8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside	Structural Classification Polysaccharides Source classification Plants Valerianaceae Valeriana amurensis Smir. ex Komarov Saccharides	Others
8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside (Compound 7) is a compound derived from roots and rhizomes. 8-Hydroxypinoresinol4,4'-di-O-β-D-glucopyranoside could prevent neurotoxicity in PC12 cells .

HY-N2798

*Lariciresinol-4,4'-dimethyl ether-9-acetate*	Structural Classification Araucaria angustifolia (Bertol.) O. Kuntze Source classification Lignans Araucariaceae Phenylpropanoids Plants	Others
Lariciresinol-4,4'-dimethyl ether-9-acetate (compound IIId) is a derivative of larch resin alcohol .

HY-N11274

T-MAS 4,4-Dimethylzymosterol; 14-Norlanosterol	Structural Classification Microorganisms Terpenoids Source classification Diterpenoids	Others
T-MAS (4,4-Dimethylzymosterol) serves as an intermediate in cholesterol biosynthesis, stimulating oocytes for meiosis and modulating cumulus expansion.

HY-N1744

4,4'-Dihydroxy-2',6'-dimethoxychalcone	Structural Classification Chalcones Flavonoids Source classification Plants Alpinia galanga (L.) Willd. Zingiberaceae	Others
4,4'-Dihydroxy-2',6'-dimethoxychalcone is a Chalcones product that can be isolated from the herbs of Alpinia galanga .

HY-N8866

*3,2'-Dihydroxy-4,4'-dimethoxychalcone*	Structural Classification Chalcones Flavonoids Microorganisms Source classification	Others
3,2'-Dihydroxy-4,4'-dimethoxychalcone is a Chalcones product that can be isolated from the resins of Xanthorrhoea hastilis .

HY-N9136

*2',6'-Dihydroxy-4,4'-dimethoxychalcone*	Structural Classification Chalcones Flavonoids Source classification Plants Cephalotaxaceae Cephalotaxus sinensis (Rehder & E. H. Wilson) H. L. Li	Others
2',6'-Dihydroxy-4,4'-dimethoxychalcone is a Chalcones product that can be isolated from the herbs of Cephalotaxus sinensis .

HY-W024604

4,4-Dimethyl-2-cyclopenten-1-one 4,4-Dimethylcyclopent-2-enone	Apocynaceae Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Apocyniveneti Folium Disease Research Fields Cancer	Others
4,4-Dimethyl-2-cyclopenten-1-one, a natural compound from Apocyniveneti Folium, displays higher tumor-specific cytotoxicity .

HY-N8184

4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone	Dracaena cochinchinensis (Lour.) S. C. Chen Classification of Application Fields Source classification Phenols Polyphenols Agavaceae Plants Disease Research Fields Inflammation/Immunology	COX
4,4'-Dihydroxy-2,6-dimethoxydihydrochalcone exhibits COX-1 and COX-2 inhibitory activity .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-N13684

4-(4-Hydroxy-3-methoxyphenyl)butane-1,2-diol	Structural Classification Monophenols Calophyllum inophyllum L. Source classification Phenols Plants Calophyllaceae	Others
4-(4-Hydroxy-3-methoxyphenyl)butane-1,2-diol is a natural product .

HY-N15356

9-Oxooctadecanedioic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Quercus suber L. Fagaceae	Bacterial
9-Oxooctadecanedioic acid is an α,ω-dicarboxylic fatty acid monomer found in the cork suberin of Quercus suber. It contributes to the formation of the hydrophobic barrier structure in plant cell walls and may play an important role in functions such as water resistance and protection against microbial penetration .

HY-N9101

4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan	Structural Classification Caprifoliaceae Source classification Lignans Phenylpropanoids Viburnum cylindricum Buch.-Ham. ex D. Don Plants	Others
4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan is a lignans that can be isolated from the Viburnum foetidum. 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan has cytotoxicity against A549, SK-OV-3, SKMEL-2 and HCT15 cell line with IC₅₀s of 67.14, 67.38, 64.11 and 76.31 μg/mL, respectively .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-N12333

4,4-Di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol	Structural Classification Schisandra propinqua (Wall.) Baill. Source classification Lignans Phenols Phenylpropanoids Plants Schisandraceae	Others
4,4-Di(4-hydroxy-3-methoxyphenly)-2,3-dimethylbutanol is a Phenols product that can be isolated from the herbs of Schisandra propinqua .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	Reference Standards NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-N13198

4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside	Structural Classification Rhodiola sacra (Prain ex Raym.-Hamet) S. H. Fu Crassulaceae Source classification Phenols Polyphenols Plants	Endogenous Metabolite
4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside is a pancreatic lipase inhibitor, with an IC₅₀ value of 2.91 μM. 4-(4-Hydroxyphenyl)-2-butanone 4'-O-β-D-(2-O-galloyl-6-O-cinnamoyl)glucopyranoside can effectively reduce lipid absorption and regulate obesity-related metabolic disorders, making it useful for research on obesity .

HY-N15496

Fusaproliferin FUS	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reactive Oxygen Species (ROS) NO Synthase Interleukin Related TNF Receptor p38 MAPK ERK IKK NF-κB
Fusaproliferin is a sesterterpene mycotoxin isolated from Fusarium solani. Fusaproliferin reverse Lipopolysaccharides (HY-D1056) stimulation and the NF-κB and MAPKs signaling pathways contribute to the anti-inflammatory process. Fusaproliferin exhibits affinity for the TLR4 protein with K_D values of 28.6 μM. Fusaproliferin shows cytotoxicity against pancreatic cancer cell with rapid and sub-micromolar IC₅₀ .

HY-W011370

Pelargonidin chloride 1 Publications Verification	Structural Classification Anthocyans Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Plants Phaseolus vulgaris Linn. Disease Research Fields	Quinone Reductase Reactive Oxygen Species (ROS)
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment .

HY-N4196

4-(4'-Hydroxyphenyl)-2-butanone4'-O-β-D-(2''-O-galloyl-6''-O-p-coumaroyl)glucopyranoside	Structural Classification Polygonaceae Source classification Phenols Polyphenols Plants Rheum tanguticum	Others
4-(4'-Hydroxyphenyl)-2-butanone4'-O-β-D-(2''-O-galloyl-6''-O-p-coumaroyl)glucopyranoside is a natural product .

HY-P2274R

Argifin (Standard)	Structural Classification Natural Products Microorganisms Source classification	Reference Standards Parasite
Argifin (Standard) is the analytical standard of Argifin. This product is intended for research and analytical applications. Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

HY-N0662R

Amentoflavone (Standard) Didemethyl-ginkgetin (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reference Standards Reactive Oxygen Species (ROS) Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase .

HY-N8786

*2,4,4'-Trihydroxydihydrochalcone*	Structural Classification Chalcones Flavonoids Dracaena draco (L.) L. Source classification Agavaceae Plants	Others
2,4,4'-Trihydroxydihydrochalcone is a Chalcones product that can be isolated from the resin of Dracaena draco. .

HY-B0504S

Creatinine-d3 5 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Isotope-Labeled Compounds Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle .

HY-N1764

*3,4,4',7-Tetrahydroxyflavan*	Structural Classification Flavonols Flavonoids Source classification Plants Toxicodendron vernicifluum (Stokes) F. A. Barkl. Anacardiaceae	Others
3,4,4',7-Tetrahydroxyflavan is a Flavonoids product that can be isolated from the barks of Toxicodendron verniciflua .

HY-N14893

Cetoniacytone B	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Others
Cetoniacytone B can inhibit the growth of HEPG2 and MCF7 human tumor cell lines, with GI₅₀ values of 4.4 μM .

HY-N11129

*3',4,4',6-Tetrahydroxyaurone 4-O-β-D-glucoside*	Structural Classification Crotalaria albida Heyne ex Roth Flavonoids Flavones Leguminosae Source classification Plants	Endogenous Metabolite
3',4,4',6-Tetrahydroxyaurone 4-O-β-D-glucoside is a chalcone glucoside that can be found in Acacia dealbata .

HY-N10607

*2'-Hydroxy-3,4,4',6'-tetramethoxychalcone*	Source classification Piperaceae Plants Piper obliquum Ruiz & Pav.	Bacterial
2'-Hydroxy-3,4,4',6'-tetramethoxychalcone (Compound 5) has antibacterial activity, with a MIC value of 10 μg/mL for E. coli and S. epidermis. 2'-Hydroxy-3,4,4',6'-tetramethoxychalcone can be isolated from Piper obliquum .

HY-N13163

2-Epitripdiolide	Structural Classification Terpenoids Source classification Celastraceae Diterpenoids Tripterygium wilfordii Hook. f. Plants	Others
2-Epitripdiolide is a diterpenoid compound derived from Tripterygium hypoglaucum with significant antitumor activity. Its IC₅₀ values against A549, KB, KBvin, and MDA-MB-231 cells are 1.34, 0.4, 4.4, and 1.2 nM, respectively .

HY-N10906

*(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one*	Structural Classification Terpenoids Sesquiterpenes Source classification Plants Lauraceae Lindera aggregata (Sims) Kosterm.	Others
(4R,4aS,5aS,6aR,6bS,7aR)-4-Hydroxy-3,6b-dimethyl-5-methylene-4,4a,5,5a,6,6a,7,7a-octahydrocyclopropa[2,3]indeno[5,6-b]furan-2(6bH)-one is a sesquiterpene lactone .

HY-N11048

Amycolatopsin A	Infection Structural Classification Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields Cancer	Bacterial
Amycolatopsin A is a 20-membered macrolide, that can be isolated from a strain of the rare actinomycete Amycolatopsis sp. MST‐108494. Amycolatopsin A shows antimycobacterial activity against Mycobacterium bovis (BCG) and M. tuberculosis (H37Rv) with IC₅₀ values of 0.4 µM and 4.4 µM, respectively .

HY-N8106

*7,15-Dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic acid*	Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Cancer	Others
7,15-Dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic acid is one of the ganoderma triterpenoids which have been recognised as an important bioactive ingredient in Ganoderma Lucidum Karst. 7,15-Dihydroxy-4,4,14-trimethyl-3,11-dioxochol-8-en-24-oic acid can be used for the research of various etiologies .

HY-155704

Lyciumamide A	Structural Classification Lycium barbarum L. Source classification Phenols Polyphenols Solanaceae Plants	PPAR
DPP-IV-IN-5 is isolated from the fruits of Lycium barbarum. DPP-IV-IN-5 exerts moderate agonistic activities for peroxisome proliferator-activated receptor (PPARγ) with EC₅₀ values of 10.09 - 44.26 μM and also presents inhibitory activity on dipeptidyl peptidase-4 (DPPIV) with an IC₅₀ value of 47.13 μM .

HY-N3806

Enniatin B	Infection Cardiovascular Disease Alkaloids Microorganisms Classification of Application Fields Source classification Disease Research Fields	Acyltransferase ERK
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

Cat. No.	Product Name	Chemical Structure

HY-W011927S

4,4'-Sulfonyldiphenol-d8 1 Publications Verification
4,4'-Sulfonyldiphenol-d₈ is the deuterium labeled 4,4'-Sulfonyldiphenol .

HY-W653930

4,4'-Sulfonyldiphenol-13C12
4,4'-Sulfonyldiphenol- ¹³C₁₂ (Bisphenol S- ¹³C₁₂) is ¹³C labeled 4,4'-Sulfonyldiphenol. 4,4'-Sulfonyldiphenol (Bisphenol S; Bis(4-hydroxyphenyl) sulfone) is a biochemical reagent that can be used as a biological material or organic compound for life science related research .

HY-W016189S

4,4'-Dihydroxybiphenyl-d8
4,4'-Dihydroxybiphenyl-d₈ is the deuterium labeled 4,4'-Dihydroxybiphenyl .

HY-B1955S

4',4-Dibromobiphenyl-d8
4',4-Dibromobiphenyl-d₈ is the deuterium labeled 4',4-Dibromobiphenyl[1].

HY-B1986S

p,p'-DDE-d8
p,p'-DDE-d₈ is the deuterium labeled p,p'-DDE . p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC₅₀ of 5 μM and a K_i of 3.5 μM .

HY-W767978

*1-(4,4-Dimethylthiochroman-6-yl)ethanone-d8*
1-(4,4-Dimethylthiochroman-6-yl)ethanone-d₈ (6-Acetyl-4,4-dimethylthio-chroman-d₈) is the deuterium labeled 1-(4,4-Dimethylthiochroman-6-yl)ethanone (HY-I0187).

HY-W777094

*1-Acetyl-4-(4-hydroxyphenyl)piperazine-d8*
1-Acetyl-4-(4-hydroxyphenyl)piperazine-d₈ (Tetraethoxy C methyl propane-d₈) is the deuterium labeled 1-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone (HY-W014037).

HY-B1984S

p,p'-DDD-d8

p,p'-DDD-d₈ is the deuterium labeled p,p'-DDD[1]. p,p'-DDD (4,4’-DDD) is an organochlorine insecticide, a major metabolite of p,p'-DDT. p,p'-DDD is an agonist at estrogen receptor α(ERα) and ERβ. p,p'-DDD increases DNA damage, apoptosis and necrosis in peripheral blood. p,p'-DDD stimulates cell proliferation in SKBR3 cells. p,p'-DDD activates the AP-1 transcription factor. p,p'-DDD decreases sleep times of barbiturates and steroids in rats .

HY-W024986S

4-(4-Hexoxyphenyl)benzonitrile-13C6
4-(4-Hexoxyphenyl)benzonitrile- ¹³C₆ (4'-Hexyloxy-4-biphenylcarbonitrile- ¹³C₆) is the ¹³C-labeled 4-(4-Hexoxyphenyl)benzonitrile.

HY-W699637

4-[[(4-Fluorophenyl)imino]methyl]phenol-d4
4-[[(4-Fluorophenyl)imino]methyl]phenol-d₄ (4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol-d₄) is the deuterium labeled 4-[[(4-Fluorophenyl)imino]methyl]phenol (HY-W014178).

HY-B0688S

Dapsone-d8
Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases .

HY-W142647S

*2,2'-Dihydroxy-4,4'-dimethoxybenzophenone-d6*
2,2'-Dihydroxy-4,4'-dimethoxybenzophenone-d₆ (Bis(2-hydroxy-4-methoxyphenyl)methanone-d₆) is deuterium labeled 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone .

HY-W242724

*1,4-Dibromo-butane-1,1,2,2,3,3,4,4-d8*
1,4-Dibromo-butane-1,1,2,2,3,3,4,4-d₈ is the deuterium labeled 1,4-Dibromo-butane .

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-N0067S2

*γ-Aminobutyric acid-4,4-d2*
γ-Aminobutyric acid-4,4-d₂ is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].

HY-B0688S3

Dapsone-15N2

Dapsone- ¹⁵N₂ (4,4′-Diaminodiphenyl sulfone- ¹⁵N₂) is ¹⁵N labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-W654082

Bisphenol e-13C6
Bisphenol e- ¹³C₆ is ¹³C labeled Bisphenol E. Bisphenol E (4,4'-Ethylidenediphenol) is a biochemical reagent .

HY-42118S

4-(4-Fluorobenzylamino)-1-methylpiperidine-d2
4-(4-Fluorobenzylamino)-1-methylpiperidine-d₂ (N-[(4-Fluorophenyl)methyl]-1-methyl-4-piperidinamine-d₂) is the deuterium labeled 4-(4-Fluorobenzylamino)-1-methylpiperidine.

HY-W751537

4-[[(4-Fluorophenyl)imino]methyl]phenol-13C6
4-[[(4-Fluorophenyl)imino]methyl]phenol- ¹³C₆ (4-{(E)-[(4-Fluorophenyl)imino]methyl}phenol- ¹³C₆) is the ¹³C-labeled 4-[[(4-Fluorophenyl)imino]methyl]phenol (HY-W014178).

HY-B0688S1

Dapsone-d4

Dapsone-d₄ is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-W009293S

1-(Bis(4-fluorophenyl)methyl)piperazine-d4
1-(Bis(4-fluorophenyl)methyl)piperazine-d₄ (N-(4,4-Difluorobenzhydryl)piperazine-d₄) is the deuterium labeled 1-(Bis(4-fluorophenyl)methyl)piperazine.

HY-12085S1

Apremilast-d8
Apremilast-d₈ (CC-10004-d₈) is deuterium labeled Apremilast. Apremilast (CC-10004) is an orally available inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4) with an IC₅₀ of 74 nM. Apremilast inhibits TNF-α release by lipopolysaccharide (LPS) with an IC₅₀ of 104 nM .

HY-W740498

Raspberry ketone-d5
Raspberry ketone-d₅ (Frambione-d₅; 4-(4-Hydroxyphenyl)-2-butanone-d₅) is the deuterium labeled Raspberry ketone (HY-N1426). Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff; also shows PPAR-α agonistic activity.

HY-103332S

N-Arachidonylglycine-d8

N-Arachidonylglycine-d8 is a deuterated labeled N-Arachidonylglycine . N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC₅₀ = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC₅₀ = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration .

HY-14806S

Teneligliptin-d8
Teneligliptin-d₈ is a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting DPP-4 inhibitor .

HY-17037S1

Pirenzepine-d8 dihydrochloride

Pirenzepine-d₈ (LS 519-d₈; Pirenzepin-d₈) dihydrochloride is a deuterium labeled Pirenzepine (dihydrochloride) (HY-17037). Pirenzepine (LS 519) dihydrochloride is a selective M1 mAChR (muscarinic acetylcholine receptor) antagonist. Pirenzepine dihydrochloride reduces gastric acid secretion and reduces muscle spasm, can be used in peptic ulcers research. Pirenzepine dihydrochloride shows anti-proliferative activity to cancer cells .

HY-G0021S

N-Desmethylclozapine-d8

N-Desmethylclozapine-d₈ is the deuterium labeled N-Desmethylclozapine. N-Desmethylclozapine is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine is a potent, allosteric and partial M1 receptors agonist (EC₅₀=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine is also a δ-opioid agonist .

HY-G0021S1

N-Desmethylclozapine-d8 hydrochloride

N-Desmethylclozapine-d₈ (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC₅₀=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist .

HY-B0615AS

Moricizine-d8(Hydrochloride)
Moricizine-d₈ (Hydrochloride) is the deuterium labeled Moricizine Hydrochloride (HY-B0615A). Moricizine Hydrochloride is an orally active Class I antiarrhythmic agent. Moricizine Hydrochloride decreases the maximum rate of phase 0 depolarization; increases rates of phase 2 and 3 repolarization, decreases action potential duration, and decreases effective refractory period .

HY-W748758

(Z)-Thiothixene-d8

(Z)-Thiothixene-d₈ (NSC 108165-d₈; Navan-d₈; Navane-d₈) is the deuterium labeled Thiothixene (HY-A0139). Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1, D3, and D4 receptors (Kis=0.417, 338, 186.2, and 363.1 nM, respectively). Thiothixene also binds to various serotonin (5-HT), histamine H1, α1- and α2-adrenergic, muscarinic acetylcholine, and sigma receptors (Kis=15-5,754 nM) as well as the dopamine, norepinephrine, and serotonin transporters (Kis=3.16-30 μM). In vivo, thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition, as measured by a decreased lick latency in response to light and foot shock stimuli, which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice, indicating antidepressant-like behavior.

HY-W753141

p,p'-DDE-13C12
p,p'-DDE- ¹³C₁₂ is ¹³C labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC₅₀ of 5 μM and a K_i of 3.5 μM .

HY-50896S3

Erlotinib-d8

Erlotinib-d₈ (CP-358774-d₈) is deuterium labeled Erlotinib. Erlotinib (CP-358774) is a directly acting EGFR tyrosine kinase inhibitor, with an IC₅₀ of 2 nM for human EGFR. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC₅₀ of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer . Erlotinib is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14740S

Elvitegravir-d8
Elvitegravir-d₈ is deuterium labeled Elvitegravir. Elvitegravir (GS-9137; JTK-303; D06677) is an HIV integrase inhibitor for HIV-1IIIB, HIV-2EHO and HIV-2ROD with IC50 of 0.7 nM, 2.8 nM and 1.4 nM, respectively.

HY-17037S

Pirenzepine-d8
Pirenzepine-d₈ is the deuterium labeled Pirenzepine dihydrochloride. Pirenzepine dihydrochloride (LS519) is a selective M1 muscarinic receptor antagonist.

HY-10227S

Bortezomib-d8
Bortezomib-d₈ is the deuterium labeled Bortezomib. Bortezomib (PS-341) is a reversible and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki=0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is the first proteasome inhibitor anticancer agent. Anti-cancer activity .

HY-10570S2

Nevirapine-d8
Nevirapine-d₈ (BI-RG 587-d₈) is deuterium labeled Nevirapine. Nevirapine is a non-nucleoside inhibitor of HIV-1 reverse transcriptase used to treat and prevent HIV/AIDS; with a K_i of 270 μM .

HY-15531S

Venetoclax-d8
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy .

HY-13463BS

Avatrombopag-d8 hydrochloride

Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-13011S

Alectinib-d8
Alectinib-d₈ is the deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC₅₀ of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC₅₀s of 1 nM and 3.5 nM, respectively . Alectinib demonstrates effective central nervous system (CNS) penetration .

HY-15581S

MMAD-d8
MMAD-d₈D is a deuterated form of MMAD, which is a microtubule disrupting agent.

HY-Y1309S

1-Naphthol-d8
1-Naphthol-d₈ is the deuterium labeled 1-Naphthol . 1-naphthol is an excited state proton transfer (ESPT) fluorescent molecular probe .

HY-W771024

Butane-1,4-diyl bis(4-methylbenzenesulfonate)-13C4
Butane-1,4-diyl bis(4-methylbenzenesulfonate)- ¹³C₄ (4-(4-Methylphenyl)sulfonyloxybutyl 4-methylbenzenesulfonate- ¹³C₄) is the ¹³C-labeled Butane-1,4-diyl bis(4-methylbenzenesulfonate) (HY-Z1250).

HY-N0378S

D-Mannitol-d8
D-Mannitol-d₈ is the deuterium labeled D-Mannitol. D-Mannitol is an osmotic diuretic agent and a weak renal vasodilator.

HY-13502S

Mitoxantrone-d8
Mitoxantrone-d₈ (mitozantrone-d₈) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM .

HY-B0246S2

Carbamazepine-d8
Carbamazepine-d₈ is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC₅₀ of 131 μM .

HY-N0623S5

L-Tryptophan-d8
L-Tryptophan-d₈ is the deuterium labeled L-Tryptophan. L-Tryptophan (Tryptophan) is an essential amino acid that is the precursor of serotonin, melatonin, and vitamin B3 .

HY-B0272S1

Rifampicin-d8
Rifampicin-d8 (Rifampin-d8) is the deuterium labeled Rifampicin. Rifampicin is a potent and broad spectrum antibiotic against bacterial pathogens. Rifampicin has anti-influenza virus activities.

HY-N0007S

Bisdemethoxycurcumin-d8

Bisdemethoxycurcumin-d₈ (Curcumin III-d₈) is the deuterium labeled Bisdemethoxycurcumin (HY-N0007A). Bisdemethoxycucurmin (Curcumin III) is a curcuminoid compound and an inhibitor of P-glycoprotein and ferroptosis. Bisdemethoxycucurmin exhibits multiple activities such as anti-oxidation, anti-inflammation and anti-tumor. Bisdemethoxycucurmin can be used for the research of tumors and inflammatory diseases .

HY-B0104S2

Glimepiride-d8
Glimepiride-d₈ (Glimperide-d₈; HOE-490-d₈) is deuterium-labeled Glimepiride (HY-B0104) .

HY-13502AS

Mitoxantrone-d8 dihydrochloride

Mitoxantrone-d₈ dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

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