4-(Hydroxymethyl)phenoxyacetic acid

Cat. No.: HY-W016413: Data Sheet
SDS
Handling Instructions
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4-(Hydroxymethyl)phenoxyacetic acid is an acid-labile resin linkage agent for use in solid phase peptide synthesis.

For research use only. We do not sell to patients.

4-(Hydroxymethyl)phenoxyacetic acid Chemical Structure

CAS No. : 68858-21-9

Size	Stock	Quantity
Free Sample (0.1 - 0.2 mg)	Apply Now
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
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Purity & Documentation
References
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Description

4-(Hydroxymethyl)phenoxyacetic acid is an acid-labile resin linkage agent for use in solid phase peptide synthesis^[1].

Molecular Weight

182.18

Formula

C₉H₁₀O₄

CAS No.

68858-21-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)COC1=CC=C(CO)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (548.92 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.4892 mL	27.4461 mL	54.8923 mL
5 mM	1.0978 mL	5.4892 mL	10.9785 mL
10 mM	0.5489 mL	2.7446 mL	5.4892 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (266 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. C T Bui, et al. Improving the performance of an acid-labile 4-hydroxymethyl phenoxyacetic acid (HMP) linker on resin and SynPhase grafted solid-supports. J Pept Sci. 2000 Oct;6(10):534-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.4892 mL	27.4461 mL	54.8923 mL	137.2307 mL
	5 mM	1.0978 mL	5.4892 mL	10.9785 mL	27.4461 mL
	10 mM	0.5489 mL	2.7446 mL	5.4892 mL	13.7231 mL
	15 mM	0.3659 mL	1.8297 mL	3.6595 mL	9.1487 mL
	20 mM	0.2745 mL	1.3723 mL	2.7446 mL	6.8615 mL
	25 mM	0.2196 mL	1.0978 mL	2.1957 mL	5.4892 mL
	30 mM	0.1830 mL	0.9149 mL	1.8297 mL	4.5744 mL
	40 mM	0.1372 mL	0.6862 mL	1.3723 mL	3.4308 mL
	50 mM	0.1098 mL	0.5489 mL	1.0978 mL	2.7446 mL
	60 mM	0.0915 mL	0.4574 mL	0.9149 mL	2.2872 mL
	80 mM	0.0686 mL	0.3431 mL	0.6862 mL	1.7154 mL
	100 mM	0.0549 mL	0.2745 mL	0.5489 mL	1.3723 mL